Compound Q&A

How is 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine (CAS: 448964-37-2) typically synthesized?

Answer

2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine
2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine can be synthesized via a multistep process involving the Wittig reaction followed by amine coupling. The key steps include the preparation of the indeno-furan derivative, followed by treatment with an appropriate alkyl halide in the presence of a base to form the ethyl amine derivative. The overall reaction is typically carried out under mild conditions, with yields ranging from 70-85%.

About

English Name 2,6,7,8-Tetrahydro-1H-indeno[5,4-b]furan-8-ylethylamine
Molecular Formula C13H17NO
Molecular Weight 203.28 g/mol
SMILES C1CC2=C(C1CCN)C3=C(C=C2)OCC3
InChIKey BFNUHWYOQCGTCA-UHFFFAOYSA-N
Last Updated: 2025-12-25 22:28

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