1,2-Dihydro Dexamethasone

Basic Information

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CAS Number

426-17-5

Molecular Formula

C22H31FO5

Molecular Weight

394.48 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Polymers and Plastics Thermoplastics Polyolefins

Basic Physical Properties

SMILES

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C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)CC[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)CO

InChI

InChI=1S/C22H31FO5/c1-12-8-16-15-5-4-13-9-14(25)6-7-19(13,2)21(15,23)17(26)10-20(16,3)22(12,28)18(27)11-24/h9,12,15-17,24,26,28H,4-8,10-11H2,1-3H3/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1

InChIKey

YYZXYYHUGHQGHI-CXSFZGCWSA-N

LogP

2.1197000000000004

Topological Polar Surface Area

94.83 Å²

Hydrogen Bond Donor/Acceptor

3 / 5

Synonyms & References

English

1,2-Dihydro Dexamethasone
Dexamethasone
(8S,9R,10S,11S,13S,14S,16R,17R)-9-fluoro-11,17-dihydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-1,2,6,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-3H-cyclopenta[a]phenanthren-3-one

MDL Number

MFCD22683747

FAQ

What are the physical and chemical properties of 1,2-Dihydro Dexamethasone (CAS: 426-17-5)?

1,2-Dihydro Dexamethasone is a white crystalline powder with a molecular weight of approximately 476.65 g/mol. It is slightly soluble in water and ethanol. Chemically, it is highly reactive due to the presence of functional groups such as the hydroxyl and methyl groups. It undergoes hydrolysis and oxidation readily.

How is 1,2-Dihydro Dexamethasone (CAS: 426-17-5) typically synthesized?

1,2-Dihydro Dexamethasone is typically synthesized by reducing dexamethasone with sodium borohydride or lithium aluminum hydride. The reaction involves the reduction of the C17-ester to a hydroxyl group, resulting in a highly selective and efficient synthesis with good yields.

What industries use 1,2-Dihydro Dexamethasone (CAS: 426-17-5)?

1,2-Dihydro Dexamethasone is primarily used in the pharmaceutical industry for the production of corticosteroid medications. It is also utilized in research and development for its anti-inflammatory and immunosuppressive properties.

What precautions should be taken when handling 1,2-Dihydro Dexamethasone (CAS: 426-17-5)?

When handling 1,2-Dihydro Dexamethasone, it is crucial to use personal protective equipment (PPE) such as gloves and safety goggles. Work in a well-ventilated area or fume hood to minimize exposure. Spills should be cleaned up using appropriate procedures as outlined in the Safety Data Sheet (SDS).