4-Amino-2-chloro-5-hydroxybenzenesulfonamide

Basic Information

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CAS Number

41606-65-9

Molecular Formula

C6H7ClN2O3S

Molecular Weight

222.65 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Melting Point

225-230°C

Boiling Point

487.8°Cat760mmHg

Density

1.699

Flash Point

248.8°C

Refractive Index

1.673

SMILES

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C1=C(C(=CC(=C1Cl)S(=O)(=O)N)O)N

InChI

InChI=1S/C6H7ClN2O3S/c7-3-1-4(8)5(10)2-6(3)13(9,11)12/h1-2,10H,8H2,(H2,9,11,12)

InChIKey

WUDOEWHXJCBYJH-UHFFFAOYSA-N

LogP

0.2752000000000001

Topological Polar Surface Area

106.41 Å²

Hydrogen Bond Donor/Acceptor

5 / 5

Complexity

276

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

2-amino-4-chlorophenol-5-sulphonamide
Q9C9PFG66G
W-106299
MFCD02684420
EINECS 255-454-4
AKOS016845860
NS00031014
SCHEMBL3575799
4-Amino-2-chloro-5-hydroxybenzenesulphonamide
AS-14560
2-Aminophenol-4-chloro-5-sulfonamide
4-Amino-2-chloro-5-hydroxybenzensulfonamide
DTXSID3068330
41606-65-9
4-amino-2-chloro-5-hydroxybenzenesulfonamide
FT-0639725
A825606
2-Amino-4-chloro-5-sulfamoylphenol
Benzenesulfonamide, 4-amino-2-chloro-5-hydroxy-
4-azanyl-2-chloranyl-5-oxidanyl-benzenesulfonamide
4-Amino-2-chloro-5-hydroxybenzenesulfonamide
2-Amino-4-Chlorophenol-5-Sulfonamide
2-Chloro-4-Amino-5-Hydroxy Benzen Sulfonamide
1-Phenol-3-sulfonamide,6-amino-4-chloro- (5CI)

MDL Number

MFCD02684420

Customs Code

2935009090

FAQ

What are the physical and chemical properties of 4-Amino-2-chloro-5-hydroxybenzenesulfonamide (CAS: 41606-65-9)?

4-Amino-2-chloro-5-hydroxybenzenesulfonamide is a white to off-white crystalline solid with a molecular weight of approximately 315.65 g/mol. It has a pKa value of about 6.4 and is moderately soluble in water. The compound is known for its reactivity, particularly in nucleophilic substitution reactions.

How is 4-Amino-2-chloro-5-hydroxybenzenesulfonamide (CAS: 41606-65-9) typically synthesized?

4-Amino-2-chloro-5-hydroxybenzenesulfonamide is synthesized through a multistep process involving the chlorination of a benzene derivative, followed by sulfonation and alkylation. Commonly, this compound is prepared using sulfuric acid and chlorine gas as reagents, with careful control of reaction conditions to achieve high selectivity and yield.

What industries use 4-Amino-2-chloro-5-hydroxybenzenesulfonamide (CAS: 41606-65-9)?

4-Amino-2-chloro-5-hydroxybenzenesulfonamide finds applications in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the polymer industry for the development of functional materials. Additionally, it can be employed in the manufacture of sensors and electronic devices due to its chemical properties.

What precautions should be taken when handling 4-Amino-2-chloro-5-hydroxybenzenesulfonamide (CAS: 41606-65-9)?

When handling 4-Amino-2-chloro-5-hydroxybenzenesulfonamide, safety precautions include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a dry, well-ventilated area away from direct sunlight and heat sources. In case of a spill, use appropriate containment barriers and follow the manufacturer's safety data sheet (SDS) guidelines for disposal.