4-Amino-2-chloro-5-hydroxybenzenesulfonamide(CAS: 41606-65-9)

4-Amino-2-chloro-5-hydroxybenzenesulfonamide is a white to off-white crystalline solid with a molecular weight of approximately 315.65 g/mol. It has a pKa value of about 6.4 and is moderately soluble in water. The compound is known for its reactivity, particularly in nucleophilic substitution reactions.

4-Amino-2-chloro-5-hydroxybenzenesulfonamide is synthesized through a multistep process involving the chlorination of a benzene derivative, followed by sulfonation and alkylation. Commonly, this compound is prepared using sulfuric acid and chlorine gas as reagents, with careful control of reaction conditions to achieve high selectivity and yield.

4-Amino-2-chloro-5-hydroxybenzenesulfonamide finds applications in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in the polymer industry for the development of functional materials. Additionally, it can be employed in the manufacture of sensors and electronic devices due to its chemical properties.

When handling 4-Amino-2-chloro-5-hydroxybenzenesulfonamide, safety precautions include wearing appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be stored in a dry, well-ventilated area away from direct sunlight and heat sources. In case of a spill, use appropriate containment barriers and follow the manufacturer's safety data sheet (SDS) guidelines for disposal.