2-Fluoro-4-nitroaniline

Basic Information

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CAS Number

369-35-7

Molecular Formula

C6H5FN2O2

Molecular Weight

156.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

133.0 to 137.0 deg-C

Boiling Point

317.2℃ at 760 mmHg

Water Solubility

Slightly soluble in water.

Flash Point

145.6℃

SMILES

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C1=CC(=C(C=C1[N+](=O)[O-])F)N

InChI

InChI=1S/C6H5FN2O2/c7-5-3-4(9(10)11)1-2-6(5)8/h1-3H,8H2

InChIKey

LETNCFZQCNCACQ-UHFFFAOYSA-N

LogP

2.42050

Complexity

159

Safety Information

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GHS Hazard Pictograms

H302

H312

H332

Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H312 Harmful in contact with skin
Acute toxicity, dermal

H332 Harmful if inhaled
Acute toxicity, inhalation

Hazard Class

Class IRRITANT Class IRRITANT

Class IRRITANT-HARMFUL Class IRRITANT-HARMFUL

Synonyms & References

English

EINECS 206-719-8
Aniline, 2-fluoro-4-nitro-
2-fluoro-4-nitrobenzenamine
F0798
2-Fluoro-4-nitroaniline, 95%
2-fluoro-4-nitrophenylamine
DTXSID10190380
2-Fluoro-4-nitroaniline
NSC-402982
AKOS005215748
SY017177
NSC402982
EN300-55886
LETNCFZQCNCACQ-UHFFFAOYSA-N
AS-13216
FT-0655070
BCP05877
CS-W002161
2-fluoro-4-nitro-phenylamine
SCHEMBL307768
(2-Fluoro-4-nitrophenyl)amine
AM61494
NS00041732
MFCD00034560
4-Nitro-2-fluoroaniline
AC-443
Z381352378
Benzenamine, 2-fluoro-4-nitro-
J-509424
SB76026
8F5CX67PNQ

MDL Number

MFCD00034560

Customs Code

2921420090

FAQ

What are the physical and chemical properties of 2-Fluoro-4-nitroaniline (CAS: 369-35-7)?

2-Fluoro-4-nitroaniline is a crystalline compound with a molecular weight of approximately 177.04 g/mol. It is slightly soluble in water and more soluble in organic solvents such as acetone and ethanol. The compound is known for its strong reactivity towards nucleophiles and reducing agents. It has a melting point of 119-121°C and a boiling point of 217-218°C under reduced pressure.

How is 2-Fluoro-4-nitroaniline (CAS: 369-35-7) typically synthesized?

2-Fluoro-4-nitroaniline is typically synthesized by the nitration of 2-fluorobenzenesulfonamide. The process involves the use of a nitrating agent such as nitric acid and sulfuric acid mixture. The reaction is carried out under controlled conditions to ensure high selectivity and yield. Commonly, the product is purified using recrystallization or distillation techniques.

What industries use 2-Fluoro-4-nitroaniline (CAS: 369-35-7)?

2-Fluoro-4-nitroaniline finds applications primarily in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). It is also used in the production of dyes and pigments, as a precursor for the synthesis of other functional materials, and in sensor technology for detecting specific chemicals.

What precautions should be taken when handling 2-Fluoro-4-nitroaniline (CAS: 369-35-7)?

When handling 2-Fluoro-4-nitroaniline, it is crucial to wear appropriate personal protective equipment (PPE) such as safety goggles, gloves, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize exposure. Spills should be handled with care and reported to a supervisor. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.