2-Fluoro-4-nitroaniline(CAS: 369-35-7)

2-Fluoro-4-nitroaniline is a crystalline compound with a molecular weight of approximately 177.04 g/mol. It is slightly soluble in water and more soluble in organic solvents such as acetone and ethanol. The compound is known for its strong reactivity towards nucleophiles and reducing agents. It has a melting point of 119-121°C and a boiling point of 217-218°C under reduced pressure.

2-Fluoro-4-nitroaniline is typically synthesized by the nitration of 2-fluorobenzenesulfonamide. The process involves the use of a nitrating agent such as nitric acid and sulfuric acid mixture. The reaction is carried out under controlled conditions to ensure high selectivity and yield. Commonly, the product is purified using recrystallization or distillation techniques.

2-Fluoro-4-nitroaniline finds applications primarily in the pharmaceutical industry for the synthesis of active pharmaceutical ingredients (APIs). It is also used in the production of dyes and pigments, as a precursor for the synthesis of other functional materials, and in sensor technology for detecting specific chemicals.

When handling 2-Fluoro-4-nitroaniline, it is crucial to wear appropriate personal protective equipment (PPE) such as safety goggles, gloves, and a lab coat. Work should be carried out in a well-ventilated fume hood to minimize exposure. Spills should be handled with care and reported to a supervisor. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.