4-Fluoro-3-nitroaniline

Basic Information

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CAS Number

364-76-1

Molecular Formula

C6H5FN2O2

Molecular Weight

156.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

96.0 to 98.0 deg-C

Boiling Point

331.3°C at 760 mmHg

Refractive Index

1.635

SMILES

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C1=CC(=C(C=C1N)[N+](=O)[O-])F

InChI

InChI=1S/C6H5FN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H2

InChIKey

LLIOADBCFIXIEU-UHFFFAOYSA-N

LogP

2.42050

Complexity

159

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

Hazard Class

Class 6.1(b) Class 6.1(b)

Synonyms & References

English

4-Fluoro-3-nitroaniline
3-nitro-4-fluoro aniline
CS-W019572
F2190-0476
BCP18823
NSC 10293
NSC10293
NS00041701
4-fluoro-3-nitrophenylamine
D77856
Z57127374
4-Fluoro-3-nitro-aniline
CAS-364-76-1
Tox21_303736
4-F-3NA
4-12-00-01668 (Beilstein Handbook Reference)
4-Fluoro-3-nitro-benzamine; 3-Nitro-4-fluoroaniline
Q27121300
4-fluoro- 3-nitroaniline
4-fluor-3-nitro-aniline
SCHEMBL394329
(4-fluoro-3-nitrophenyl)amine
A19812
EINECS 206-665-5
4-Fluoro-3-nitrobenzenamine
UNII-R8DY9W4LRV
FT-0618486
EN300-17970
AM20060291
BRN 2210199
InChI=1/C6H5FN2O2/c7-5-2-1-4(8)3-6(5)9(10)11/h1-3H,8H

MDL Number

MFCD00007833

Customs Code

29214210

FAQ

What are the physical and chemical properties of 4-Fluoro-3-nitroaniline (CAS: 364-76-1)?

4-Fluoro-3-nitroaniline is a crystalline solid with a molecular weight of approximately 174.04 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is known for its mild reactivity, particularly towards nucleophilic substitution reactions. It has a melting point of about 105-107°C and is stable under normal storage conditions but should be handled with care due to its reactivity.

How is 4-Fluoro-3-nitroaniline (CAS: 364-76-1) typically synthesized?

4-Fluoro-3-nitroaniline can be synthesized through the nitration of 4-fluoroaniline followed by the reduction of the nitro group. Commonly, nitric acid and sulfuric acid are used as reagents for nitration, and sodium borohydride or other similar reducing agents are employed for the reduction step. The process involves several steps and requires precise control of temperature and reaction conditions to achieve high selectivity and yield.

What industries use 4-Fluoro-3-nitroaniline (CAS: 364-76-1)?

4-Fluoro-3-nitroaniline is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the production of dyes and pigments, as well as in the development of sensor materials and semiconductors. Its properties make it suitable for applications requiring specific functional groups for further chemical modifications.

What precautions should be taken when handling 4-Fluoro-3-nitroaniline (CAS: 364-76-1)?

When handling 4-Fluoro-3-nitroaniline, ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation of vapors. Spills should be cleaned up promptly using appropriate absorbents, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.