4-Fluoro-3-nitroaniline(CAS: 364-76-1)

4-Fluoro-3-nitroaniline is a crystalline solid with a molecular weight of approximately 174.04 g/mol. It is slightly soluble in water but soluble in organic solvents like ethanol and acetone. The compound is known for its mild reactivity, particularly towards nucleophilic substitution reactions. It has a melting point of about 105-107°C and is stable under normal storage conditions but should be handled with care due to its reactivity.

4-Fluoro-3-nitroaniline can be synthesized through the nitration of 4-fluoroaniline followed by the reduction of the nitro group. Commonly, nitric acid and sulfuric acid are used as reagents for nitration, and sodium borohydride or other similar reducing agents are employed for the reduction step. The process involves several steps and requires precise control of temperature and reaction conditions to achieve high selectivity and yield.

4-Fluoro-3-nitroaniline is primarily used in the pharmaceutical industry for the synthesis of various drugs. It is also utilized in the production of dyes and pigments, as well as in the development of sensor materials and semiconductors. Its properties make it suitable for applications requiring specific functional groups for further chemical modifications.

When handling 4-Fluoro-3-nitroaniline, ensure the use of personal protective equipment such as gloves, goggles, and a lab coat. Work in a well-ventilated area or a fume hood to minimize inhalation of vapors. Spills should be cleaned up promptly using appropriate absorbents, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.