Cytochalasin E

Basic Information

View in Editor

CAS Number

36011-19-5

Molecular Formula

C28H33NO7

Molecular Weight

495.57 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ketones

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

206 °C

Boiling Point

587.59°C (rough estimate)

Refractive Index

1.6290 (estimate)

SMILES

View in Editor

CC1CC=CC2C3C(O3)(C(C4C2(C(=O)NC4CC5=CC=CC=C5)OC(=O)OC=CC(C1=O)(C)O)C)C

InChI

InChI=1S/C28H33NO7/c1-16-9-8-12-19-23-27(4,35-23)17(2)21-20(15-18-10-6-5-7-11-18)29-24(31)28(19,21)36-25(32)34-14-13-26(3,33)22(16)30/h5-8,10-14,16-17,19-21,23,33H,9,15H2,1-4H3,(H,29,31)/b12-8+,14-13+/t16-,17-,19-,20-,21-,23-,26+,27+,28+/m0/s1

InChIKey

LAJXCUNOQSHRJO-ZYGJITOWSA-N

LogP

3.0889000000000015

Topological Polar Surface Area

114.46000000000001 Å²

Hydrogen Bond Donor/Acceptor

2 / 8

Complexity

986

Safety Information

View Safety Information

Hazard Statement

H300 Fatal if swallowed
Acute toxicity, oral

H310 Fatal in contact with skin
Acute toxicity, dermal

H330 Fatal if inhaled
Acute toxicity, inhalation

H361 Suspected of damaging fertility or the unborn child
Reproductive toxicity

Hazard Class

Class 6.1(a) Class 6.1(a)

Synonyms & References

English

36011-19-5
21,19-diene-1,17,22-trione, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-
Cytochalasin E from Aspergillus clavatus
NSC-175151
AKOS040741587
NSC175151
Cytochalasin E, Aspergillus clavatus
NSC 175151
6,7-Epoxy-10-phenyl-5,6,16,18-tetramethyl-21,23-dioxa-(13)cytochalas-13,19-diene-17,22-dione
21,23-Dioxa(13)cytochalasa-13,19-diene-1,17,22-trione, 6,7-epoxy-18-hydroxy-16,18-dimethyl-10-phenyl-, (7S,13E,16S,18R,19E)-
EINECS 252-835-7
MFCD00005178
Q5201338
NCGC00380287-01
SCHEMBL33617
CHEMBL494856
CCG-39859
HY-N6772
CS-0093424
DTXSID60894866
HSDB 3548
CHEBI:68201
cytochalasin e
[1,3]Dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione,3,13,14,14a,15,15a,16a,16b-octahydro-6-hydroxy-4,6,15,15a-tetramethyl-14-(phenylmethyl)-,(1E,4S,6R,7E,11aS,14S,14aS,15S,15aR,16aS,16bS)-
Cytochalasin E
[1,3]Dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione,3,13,14,14a,15,15a,16...
[1,3]Dioxacyclotridecino[4,5-d]oxireno[f]isoindole-5,10,12(4H,6H)-trione,3,13,14,14a,15,15a,16a,16b-octahydro-6-hydroxy-4,6,1
(7s,13e,16s,18r,19e)-18-dimethyl-10-phenyl
CYTOCHALACINE
CYTOCHALASIN 3
CYTOCHALICINE

MDL Number

MFCD00005178

Customs Code

29349990

FAQ

What are the physical and chemical properties of Cytochalasin E (CAS: 36011-19-5)?

Cytochalasin E (CAS: 36011-19-5) is a cyclic tetrapeptide with a molecular weight of approximately 656.45 g/mol. It is poorly water-soluble, with a solubility of about 0.002 mg/mL in water. Chemically, it is known for its reactivity towards cell walls and actin filaments, making it an important tool in cell biology research.

How is Cytochalasin E (CAS: 36011-19-5) typically synthesized?

Cytochalasin E (CAS: 36011-19-5) is typically synthesized through complex multi-step processes involving peptide coupling reactions and chemical modifications. Commonly, these syntheses involve the use of protected amino acids, followed by deprotection and coupling to form the cyclic tetrapeptide structure. The yield and selectivity of these processes are critical for obtaining pure Cytochalasin E.

What industries use Cytochalasin E (CAS: 36011-19-5)?

Cytochalasin E (CAS: 36011-19-5) is primarily used in the pharmaceutical industry for its role in cell biology research and as a tool for studying actin dynamics. It is also used in the polymer industry for its potential applications in material science and in the development of new polymers with specific properties.

What precautions should be taken when handling Cytochalasin E (CAS: 36011-19-5)?

When handling Cytochalasin E (CAS: 36011-19-5), it is essential to follow safety guidelines and use appropriate personal protective equipment (PPE) such as gloves and safety goggles. Work should be conducted in a fume hood to minimize inhalation risks. In case of a spill, use absorbent materials and clean up according to standard laboratory safety protocols. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.