Azithromycin EP Impurity B (Azithromycin B)

Basic Information

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CAS Number

307974-61-4

Molecular Formula

C38H72N2O11

Molecular Weight

733 g/mol

Basic Physical Properties

Physical State

White to Yellow

Melting Point

98-102°C

Boiling Point

795.6±60.0 °C(Predicted)

Density

1.15±0.1 g/cm3(Predicted)

Flash Point

435.0±32.9 °C

Solubility

Chloroform (Slightly), Dichloromethane (Slightly), DMSO (Slightly), Methanol (Sl

Vapor Pressure

0.0±6.3 mmHg at 25°C

SMILES

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CC[C@H]1OC(=O)[C@H](C)[C@@H](O[C@H]2C[C@@](C)(OC)[C@@H](O)[C@H](C)O2)[C@H](C)[C@@H](O[C@@H]2O[C@H](C)C[C@@H]([C@H]2O)N(C)C)[C@](C)(O)C[C@@H](C)CN(C)[C@H](C)[C@@H](O)[C@H]1C

InChI

InChI=1S/C38H72N2O11/c1-15-28-22(4)30(41)25(7)40(13)19-20(2)17-37(9,45)34(51-36-31(42)27(39(11)12)16-21(3)47-36)23(5)32(24(6)35(44)49-28)50-29-18-38(10,46-14)33(43)26(8)48-29/h20-34,36,41-43,45H,15-19H2,1-14H3/t20-,21-,22+,23+,24-,25-,26+,27+,28-,29+,30+,31-,32+,33+,34-,36+,37-,38-/m1/s1

InChIKey

JBYIGHZCRVMHAK-VINPOOLWSA-N

LogP

2.7858000000000054

pKa

13.50±0.70(Predicted)

Topological Polar Surface Area

159.85000000000002 Å²

Hydrogen Bond Donor/Acceptor

4 / 13

Safety Information

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Hazard Statement

Synonyms & References

English

AZITHROMYCIN IMPURITY B
AzithroMycin B
Azithromycin EP Impurity B
(2R,3R,4R,5R,8R,10R,11R,12R,13S,14R)-11-(((2S,3S,4S)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-4,10-dihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-
Azithromycin EP mpurity B
Azithromycin EP Impurity B/(2R,3R,4S,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-4,10-dihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,
Azithromycin Impurit Ⅱ:( Impurit B)(Azithromycin B) (2R,3R,4S,5R,8R,10R,11R,12S,13S,14R)-13-[(2,6-Dideoxy-3-C-methyl-3-O-methyl-α-L-ribo-hexopyranosyl)oxy]-2-ethyl-4,10-dihydroxy-3,5,6,8,10,12,14-heptamethyl-11-[[3,4,6-trideoxy-3-(dimethylamino)-β-D-xylo-
(2R,3R,4S,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-4,10-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]oxy-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one
(2R,3R,4S,5R,8R,10R,11R,12S,13S,14R)-11-[(2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyloxan-2-yl]oxy-2-ethyl-4,10-dihydroxy-13-[(2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyloxan-2-yl]ox
Azithromycin B
(2R,3R,4S,5R,8R,10R,11R,12S,13S,14R)-11-(((2S,3R,4S,6R)-4-(dimethylamino)-3-hydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)-2-ethyl-4,10-dihydroxy-13-(((2R,4R,5S,6S)-5-hydroxy-4-methoxy-4,6-dimethyltetrahydro-2H-pyran-2-yl)oxy)-3,5,6,8,10,12,14-heptamethyl-1-oxa-6-azacyclopentadecan-15-one

FAQ

What are the physical and chemical properties of Azithromycin EP Impurity B (CAS: 307974-61-4)?

Azithromycin EP Impurity B (CAS: 307974-61-4) is a crystalline compound with a molecular weight of approximately 801.86 g/mol. It has a solubility of about 10 mg/mL in water and is relatively stable under normal conditions. The compound shows limited reactivity, making it suitable for various pharmaceutical applications. It is soluble in organic solvents like methanol and ethanol but less so in non-polar solvents. It is important to handle the compound under appropriate conditions to avoid degradation.

How is Azithromycin EP Impurity B (CAS: 307974-61-4) typically synthesized?

Azithromycin EP Impurity B (CAS: 307974-61-4) is synthesized through a complex route involving multiple steps. Commonly, it is produced from azithromycin through a series of chemical transformations. The process involves selective hydrogenation, amidation, and other reactions, utilizing catalysts such as palladium on carbon. The overall yield is moderate, and the method is optimized for selectivity and purity. Detailed procedures and conditions are typically found in research literature and patent documents.

What industries use Azithromycin EP Impurity B (CAS: 307974-61-4)?

Azithromycin EP Impurity B (CAS: 307974-61-4) is primarily used in the pharmaceutical industry. It serves as a key component in the development and manufacturing of azithromycin-based medications. While it is not directly used in the production of polymers, sensors, or semiconductors, it plays a crucial role in ensuring the quality and purity of azithromycin formulations. Its presence is monitored during quality control checks to ensure the final product meets regulatory standards.

What precautions should be taken when handling Azithromycin EP Impurity B (CAS: 307974-61-4)?

When handling Azithromycin EP Impurity B (CAS: 307974-61-4), it is essential to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be managed quickly by using absorbent materials and following appropriate cleanup procedures. Always refer to the safety data sheet (SDS) for detailed instructions and emergency response measures. Storage should be in a cool, dry place, away from heat and direct sunlight.