[Pyr1]-Apelin-13

Basic Information

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CAS Number

217082-60-5

Molecular Formula

C69H108N22O16S

Molecular Weight

1533.8 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)CC(C(=O)NC(CO)C(=O)NC(CC1=CN=CN1)C(=O)NC(CCCCN)C(=O)NCC(=O)N2CCCC2C(=O)NC(CCSC)C(=O)N3CCCC3C(=O)NC(CC4=CC=CC=C4)C(=O)O)NC(=O)C(CCCN=C(N)N)NC(=O)C5CCCN5C(=O)C(CCCN=C(N)N)NC(=O)C6CCC(=O)N6

InChI

InChI=1S/C69H108N22O16S/c1-39(2)32-47(85-57(96)43(17-9-26-76-68(71)72)82-63(102)52-20-12-29-90(52)65(104)45(18-10-27-77-69(73)74)83-58(97)44-22-23-54(93)80-44)59(98)88-50(37-92)61(100)86-48(34-41-35-75-38-79-41)60(99)81-42(16-7-8-25-70)56(95)78-36-55(94)89-28-11-19-51(89)62(101)84-46(24-31-108-3)66(105)91-30-13-21-53(91)64(103)87-49(67(106)107)33-40-14-5-4-6-15-40/h4-6,14-15,35,38-39,42-53,92H,7-13,16-34,36-37,70H2,1-3H3,(H,75,79)(H,78,95)(H,80,93)(H,81,99)(H,82,102)(H,83,97)(H,84,101)(H,85,96)(H,86,100)(H,87,103)(H,88,98)(H,106,107)(H4,71,72,76)(H4,73,74,77)/t42-,43-,44-,45-,46-,47-,48-,49-,50-,51-,52-,53-/m0/s1

InChIKey

GGMAXEWLXWJGSF-PEWBXTNBSA-N

LogP

-5.446599999999987

Topological Polar Surface Area

592.9599999999999 Å²

Hydrogen Bond Donor/Acceptor

23 / 38

Complexity

3160

Synonyms & References

English

p-Glu-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe
BDBM50014619
Pyr-apelin-13
5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-L-phenylalanine
p-Glu-RPRLSHKGPMPF
NCGC00167298-01
(pGlu1)apelin-13
(Glp1)-Apelin-13, human, bovine
CHEMBL3184840
L-p-Glu-L-Arg-L-Pro-L-Arg-L-Leu-L-Ser-L-His-L-Lys-Gly-L-Pro-L-Met-L-Pro-L-Phe
Glp1-Apelin-13 human bovine
(Pyr1)apelin-13
MFCD01863147
[Pyr1]-Apelin-13
[Pyr1]apelin-13
[pGlu1]-Apelin-13
AKOS024457089
217082-60-5
(Pyr1)-Apelin-13 (human, bovine, mouse, rat) trifluoroacetate (H-Pyr-Arg-Pro-Arg-Leu-Ser-His-Lys-Gly-Pro-Met-Pro-Phe-OH)
(Glp1)-Apelin-13
CHEBI:138186
[Pyr1]-Apelin 13
L-Phenylalanine, 5-oxo-L-Prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-
L-Phenylalanine,5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-prolyl-
(Pyr1)-Apelin-13 (human, bovine, mouse, rat)
L-Phenylalanine,5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysy...
L-Phenylalanine,5-oxo-L-prolyl-L-arginyl-L-prolyl-L-arginyl-L-leucyl-L-seryl-L-histidyl-L-lysylglycyl-L-prolyl-L-methionyl-L-
GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
GLP-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE: GRPRLSHKGPMPF
PGLU-ARG-PRO-ARG-LEU-SER-HIS-LYS-GLY-PRO-MET-PRO-PHE
pQRPRLSHKGPMPF

MDL Number

MFCD01863147

FAQ

What are the physical and chemical properties of [Pyr1]-Apelin-13 (CAS: 217082-60-5)?

[Pyr1]-Apelin-13 is a peptide with a molecular weight of approximately 721.56 g/mol. It is somewhat soluble in water and has a crystalline form. The compound is stable under normal conditions but reacts with bases to form salts. It is not flammable but should be handled with care due to potential irritancy.

How is [Pyr1]-Apelin-13 (CAS: 217082-60-5) typically synthesized?

[Pyr1]-Apelin-13 is synthesized via solid-phase peptide synthesis (SPPS) using Fmoc chemistry. The synthesis involves the stepwise addition of amino acids to a growing peptide chain on a solid support. Commonly used catalysts include HATU or DCC. The final product is cleaved from the solid support using strong acids like trifluoroacetic acid (TFA).

What industries use [Pyr1]-Apelin-13 (CAS: 217082-60-5)?

[Pyr1]-Apelin-13 is primarily used in the pharmaceutical industry for research and development of potential therapeutic agents. It is also used in biological and medical research to study the apelin receptor. Limited applications exist in polymer and sensor industries due to its specific biological activity.

What precautions should be taken when handling [Pyr1]-Apelin-13 (CAS: 217082-60-5)?

When handling [Pyr1]-Apelin-13, wear appropriate personal protective equipment (PPE) such as gloves and goggles. Store the compound in a cool, dry place away from direct sunlight. Use a fume hood during synthesis and handling to minimize exposure. In case of spill, immediately follow the safety data sheet (SDS) guidelines for disposal and clean-up. Seek medical advice if exposed to the compound. Ensure proper ventilation and disposal methods are in place to prevent environmental contamination.