Biotin-PEG6-NHS ester

Basic Information

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CAS Number

2055045-04-8

Molecular Formula

C29H48N4O12S

Molecular Weight

676.79 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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O=C(ON1C(CCC1=O)=O)CCOCCOCCOCCOCCOCCOCCNC(CCCC[C@@H]2SC[C@]([C@]2([H])N3)([H])NC3=O)=O

InChI

InChI=1S/C29H48N4O12S/c34-24(4-2-1-3-23-28-22(21-46-23)31-29(38)32-28)30-8-10-40-12-14-42-16-18-44-20-19-43-17-15-41-13-11-39-9-7-27(37)45-33-25(35)5-6-26(33)36/h22-23,28H,1-21H2,(H,30,34)(H2,31,32,38)/t22-,23-,28-/m0/s1

InChIKey

QWDVPTVNWZPKBQ-LXWOLXCRSA-N

LogP

-0.0746999999999921

Topological Polar Surface Area

189.29 Å²

Hydrogen Bond Donor/Acceptor

3 / 16

Complexity

945

Synonyms & References

English

Biotin-PEG6-NHS ester
(+)-Biotin-PEG6-NHS Ester

MDL Number

MFCD22056308

FAQ

What are the physical and chemical properties of Biotin-PEG6-NHS ester (CAS: 2055045-04-8)?

Biotin-PEG6-NHS ester (CAS: 2055045-04-8) is a polymer conjugate with a molecular weight of approximately 1000 Da. It has a crystalline form and is poorly soluble in water but soluble in organic solvents. This compound is highly reactive towards amine groups, making it suitable for bioconjugation. It is used for linking biotin to proteins, polymers, and other molecules in various applications.

How is Biotin-PEG6-NHS ester (CAS: 2055045-04-8) typically synthesized?

Biotin-PEG6-NHS ester (CAS: 2055045-04-8) is synthesized by coupling biotin to a polyethylene glycol (PEG) chain using a NHS ester linker. The reaction involves the formation of an amide bond between the biotin amine group and the PEG-NHS ester. Commonly, this synthesis is performed in the presence of a catalytic amount of a coupling agent like DCC or EDC, with high selectivity and good yield.

What industries use Biotin-PEG6-NHS ester (CAS: 2055045-04-8)?

Biotin-PEG6-NHS ester (CAS: 2055045-04-8) is widely used in the pharmaceutical industry for drug delivery and targeting, in the polymer industry for modification of surfaces, and in the sensing industry for developing biosensors. It is also utilized in the semiconductor industry for functionalization of substrates.

What precautions should be taken when handling Biotin-PEG6-NHS ester (CAS: 2055045-04-8)?

When handling Biotin-PEG6-NHS ester (CAS: 2055045-04-8), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a laboratory coat. Work should be performed in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate solvents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.