Biotin-PEG6-NHS ester(CAS: 2055045-04-8)

Biotin-PEG6-NHS ester (CAS: 2055045-04-8) is a polymer conjugate with a molecular weight of approximately 1000 Da. It has a crystalline form and is poorly soluble in water but soluble in organic solvents. This compound is highly reactive towards amine groups, making it suitable for bioconjugation. It is used for linking biotin to proteins, polymers, and other molecules in various applications.

Biotin-PEG6-NHS ester (CAS: 2055045-04-8) is synthesized by coupling biotin to a polyethylene glycol (PEG) chain using a NHS ester linker. The reaction involves the formation of an amide bond between the biotin amine group and the PEG-NHS ester. Commonly, this synthesis is performed in the presence of a catalytic amount of a coupling agent like DCC or EDC, with high selectivity and good yield.

Biotin-PEG6-NHS ester (CAS: 2055045-04-8) is widely used in the pharmaceutical industry for drug delivery and targeting, in the polymer industry for modification of surfaces, and in the sensing industry for developing biosensors. It is also utilized in the semiconductor industry for functionalization of substrates.

When handling Biotin-PEG6-NHS ester (CAS: 2055045-04-8), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a laboratory coat. Work should be performed in a fume hood to minimize inhalation risks. Spills should be cleaned up with appropriate solvents and disposed of according to local regulations. Always consult the Safety Data Sheet (SDS) for detailed handling and emergency procedures.