2-Fluoro-4-methyl-3-nitropyridine

Basic Information

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CAS Number

19346-43-1

Molecular Formula

C6H5FN2O2

Molecular Weight

156.11 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

33℃

Boiling Point

264°C at 760 mmHg

SMILES

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CC1=C(C(=NC=C1)F)[N+](=O)[O-]

InChI

InChI=1S/C6H5FN2O2/c1-4-2-3-8-6(7)5(4)9(10)11/h2-3H,1H3

InChIKey

AUHFWLUBEJKXLN-UHFFFAOYSA-N

LogP

1.96050

Complexity

159

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

19346-43-1
Pyridine, 2-fluoro-4-methyl-3-nitro-
AM62420
AKOS005145668
W-206428
MFCD04112526
SCHEMBL7851282
AUHFWLUBEJKXLN-UHFFFAOYSA-N
BCP22121
FT-0649120
2-Fluoro-4-methyl-3-nitropyridine
A813644
DTXSID60496864
2-fluoro-3-nitro-4-picoline, AldrichCPR
DS-12609
2-Fluoro-3-nitro-4-picoline (2-Fluoro-4-methyl-3-nitropyridine)
2-fluoranyl-4-methyl-3-nitro-pyridine
2-fluoro-3-nitro-4-picoline
2-Fluoro-3-nitro-4-picoline
2-fluoro-3-nitro-4-methylpyridine
2-FLUORO-3-NITRO-4-PICOLINE (2-FLUORO-4-METHYL-3-NITROPYRIDINE)
2-Fluor-3-nitro-4-methylpyridin
2-fluoro-4-methyl-3-nitro-pyridine
2-Fluorol-3-nitro-4-picoline

MDL Number

MFCD04112526

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 2-Fluoro-4-methyl-3-nitropyridine (CAS: 19346-43-1)?

2-Fluoro-4-methyl-3-nitropyridine is a crystalline solid with a molecular weight of approximately 196.04 g/mol. It has limited water solubility and is soluble in organic solvents such as ethanol and acetone. It is known for its significant reactivity, particularly towards reduction and hydrolysis reactions.

How is 2-Fluoro-4-methyl-3-nitropyridine (CAS: 19346-43-1) typically synthesized?

2-Fluoro-4-methyl-3-nitropyridine is synthesized through a series of reactions including nitration of 4-methyl-3-pyridine carboxylic acid, followed by fluorination. Common catalysts include sulfuric acid for nitration and hydrogen fluoride for fluorination. The yield is around 70-80%.

What industries use 2-Fluoro-4-methyl-3-nitropyridine (CAS: 19346-43-1)?

2-Fluoro-4-methyl-3-nitropyridine is primarily used in the pharmaceutical industry for the synthesis of certain drugs. It also has applications in the development of polymers and sensors due to its unique chemical properties.

What precautions should be taken when handling 2-Fluoro-4-methyl-3-nitropyridine (CAS: 19346-43-1)?

When handling 2-Fluoro-4-methyl-3-nitropyridine, it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coats. It should be handled in a well-ventilated area or fume hood. Spills should be cleaned up using appropriate absorbent materials, and the area should be well-ventilated. Always consult the Safety Data Sheet (SDS) for specific handling and storage guidelines.