(S)-Azelastine HCl

Basic Information

View in Editor

CAS Number

153408-27-6

Molecular Formula

C22H25Cl2N3O

Molecular Weight

418.37 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

219-221?C

SMILES

View in Editor

CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl

InChI

InChI=1S/C22H24ClN3O.ClH/c1-25-13-4-5-18(12-14-25)26-22(27)20-7-3-2-6-19(20)21(24-26)15-16-8-10-17(23)11-9-16;/h2-3,6-11,18H,4-5,12-15H2,1H3;1H/t18-;/m0./s1

InChIKey

YEJAJYAHJQIWNU-FERBBOLQSA-N

LogP

4.719300000000006

Topological Polar Surface Area

38.13 Å²

Hydrogen Bond Donor/Acceptor

0 / 4

Complexity

558

Synonyms & References

English

UNII-QGN83XMX5P
SCHEMBL36771
(S)-4-[(4-Chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride
153408-27-6
Azelastine hydrochloride (S)-
1(2H)-Phthalazinone, 4-((4-chlorophenyl)methyl)-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride, (S)-
QGN83XMX5P
4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methylazepan-4-yl]-1,2-dihydrophthalazin-1-one hydrochloride
(+)-Azelastine Hydrochloride
Azelastine hydrochloride, (S)-
(S)-4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-one hydrochloride
(S)-4-(4-Chlorobenzyl)-2-(1-methylazepan-4-yl)phthalazin-1(2H)-onehydrochloride
4-[(4-Chlorophenyl)methyl]-2-[(4S)-1-methylazepan-4-yl]phthalazin-1(2H)-one--hydrogen chloride (1/1)
4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methylazepan-4-yl]phthalazin-1-one;hydrochloride
AKOS030243354
Q27287253
J-009007
DTXSID50735375
(S)-Azelastine Hydrochloride
azelastine hydrochloride
1(2H)-Phthalazinone, 4-[(4-chlorophenyl)methyl]-2-(hexahydro-1-methyl-1H-azepin-4-yl)-, monohydrochloride, (S)-
(S)-azelastine hydrochloride
4-[(4-chlorophenyl)methyl]-2-[(4S)-1-methylazepan-4-yl]phthalazin-1-one,hydrochloride
Azelastine Impurity
(S)-Azelastine Hydrochloride 2
(S)-4-[(4-Chlorophenyl)Methyl]-2-(hexahydro-1-Methyl-1H-azepin-4-yl)-1(2H)-phthalazinone Hydrochloride

MDL Number

MFCD21363435

FAQ

What are the physical and chemical properties of (S)-Azelastine HCl (CAS: 153408-27-6)?

(S)-Azelastine HCl is a white to off-white crystalline powder with a molecular weight of approximately 346.76 g/mol. It is sparingly soluble in water and ethanol. Chemically, it is stable under normal conditions but can degrade upon exposure to strong acids or bases. It exhibits mild reactivity with aromatic amines and can form complexes with metal ions.

How is (S)-Azelastine HCl (CAS: 153408-27-6) typically synthesized?

(S)-Azelastine HCl is typically synthesized via a multistep process involving the synthesis of azelastine followed by hydrochloric acid addition. Common methods include asymmetric synthesis using chiral auxiliaries or biocatalysis, with high selectivity and yield. Key steps include protection of the amine, asymmetric induction, and deprotection to yield the desired azelastine, which is then converted to its HCl salt.

What industries use (S)-Azelastine HCl (CAS: 153408-27-6)?

(S)-Azelastine HCl is primarily used in the pharmaceutical industry for the treatment of allergic rhinitis. It is also utilized in the cosmetics industry as an anti-inflammatory agent. Additionally, it has potential applications in research for studying allergenic and inflammatory responses.

What precautions should be taken when handling (S)-Azelastine HCl (CAS: 153408-27-6)?

When handling (S)-Azelastine HCl, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and contaminated materials should be disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.