(S)-Azelastine HCl(CAS: 153408-27-6)

(S)-Azelastine HCl is a white to off-white crystalline powder with a molecular weight of approximately 346.76 g/mol. It is sparingly soluble in water and ethanol. Chemically, it is stable under normal conditions but can degrade upon exposure to strong acids or bases. It exhibits mild reactivity with aromatic amines and can form complexes with metal ions.

(S)-Azelastine HCl is typically synthesized via a multistep process involving the synthesis of azelastine followed by hydrochloric acid addition. Common methods include asymmetric synthesis using chiral auxiliaries or biocatalysis, with high selectivity and yield. Key steps include protection of the amine, asymmetric induction, and deprotection to yield the desired azelastine, which is then converted to its HCl salt.

(S)-Azelastine HCl is primarily used in the pharmaceutical industry for the treatment of allergic rhinitis. It is also utilized in the cosmetics industry as an anti-inflammatory agent. Additionally, it has potential applications in research for studying allergenic and inflammatory responses.

When handling (S)-Azelastine HCl, it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be performed in a well-ventilated area or a fume hood to minimize inhalation risks. Spills should be cleaned up using appropriate absorbents, and contaminated materials should be disposed of according to local regulations. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.