Compound Q&A
How is (S)-Azelastine HCl (CAS: 153408-27-6) typically synthesized?
Answer
(S)-Azelastine HCl is typically synthesized via a multistep process involving the synthesis of azelastine followed by hydrochloric acid addition. Common methods include asymmetric synthesis using chiral auxiliaries or biocatalysis, with high selectivity and yield. Key steps include protection of the amine, asymmetric induction, and deprotection to yield the desired azelastine, which is then converted to its HCl salt.
About
CAS No
153408-27-6
English Name
(S)-Azelastine HCl
Molecular Formula
C22H25Cl2N3O
Molecular Weight
418.37 g/mol
SMILES
CN1CCCC(CC1)N2C(=O)C3=CC=CC=C3C(=N2)CC4=CC=C(C=C4)Cl.Cl
InChIKey
YEJAJYAHJQIWNU-FERBBOLQSA-N
Last Updated: 2026-03-10 14:55
