Salmon calcitonin (8-32) reduced

Basic Information

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CAS Number

151804-77-2

Molecular Formula

C127H205N37O40

Molecular Weight

2890.2 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)CC(C(=O)NC(CCC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC1=CC=C(C=C1)O)C(=O)N2CCCC2C(=O)NC(CCCNC(=N)N)C(=O)NC(C(C)O)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NCC(=O)NC(CO)C(=O)NC(CC(=O)N)C(=O)NC(C(C)O)C(=O)NC(CC3=CC=C(C=C3)O)C(=O)N)NC(=O)C(CCCCN)NC(=O)C(CC4=CNC=N4)NC(=O)C(CC(C)C)NC(=O)C(CCC(=O)O)NC(=O)C(CCC(=O)N)NC(=O)C(CO)NC(=O)C(CC(C)C)NC(=O)C(CCCCN)NC(=O)CNC(=O)C(CC(C)C)NC(=O)C(C(C)C)NC(=O)C

InChI

InChI=1S/C127H205N37O40/c1-59(2)44-81(156-122(200)99(63(9)10)142-68(15)171)105(183)139-54-96(178)143-74(22-16-18-40-128)106(184)151-84(47-62(7)8)114(192)159-90(57-166)119(197)148-77(34-37-92(130)174)108(186)146-79(36-39-98(180)181)109(187)153-83(46-61(5)6)113(191)154-85(50-71-53-137-58-141-71)115(193)145-75(23-17-19-41-129)107(185)152-82(45-60(3)4)112(190)147-78(35-38-93(131)175)111(189)162-103(67(14)170)125(203)158-88(49-70-28-32-73(173)33-29-70)126(204)164-43-21-25-91(164)120(198)149-76(24-20-42-138-127(135)136)110(188)161-102(66(13)169)124(202)157-87(52-95(133)177)117(195)160-100(64(11)167)121(199)140-55-97(179)144-89(56-165)118(196)155-86(51-94(132)176)116(194)163-101(65(12)168)123(201)150-80(104(134)182)48-69-26-30-72(172)31-27-69/h26-33,53,58-67,74-91,99-103,165-170,172-173H,16-25,34-52,54-57,128-129H2,1-15H3,(H2,130,174)(H2,131,175)(H2,132,176)(H2,133,177)(H2,134,182)(H,137,141)(H,139,183)(H,140,199)(H,142,171)(H,143,178)(H,144,179)(H,145,193)(H,146,186)(H,147,190)(H,148,197)(H,149,198)(H,150,201)(H,151,184)(H,152,185)(H,153,187)(H,154,191)(H,155,196)(H,156,200)(H,157,202)(H,158,203)(H,159,192)(H,160,195)(H,161,188)(H,162,189)(H,163,194)(H,180,181)(H4,135,136,138)/t64-,65-,66-,67-,74+,75+,76+,77+,78+,79+,80+,81+,82+,83+,84+,85+,86+,87+,88+,89+,90+,91+,99+,100+,101+,102+,103+/m1/s1

InChIKey

ZLFXHYNEZYAYPG-AABHONRUSA-N

LogP

-15.740930000000025

Topological Polar Surface Area

1275.9199999999996 Å²

Hydrogen Bond Donor/Acceptor

52 / 77

Complexity

6550

Synonyms & References

English

GTPL689
acetyl-(Asn30,Tyr32)-calcitonin8-32
AC 187
salmon calcitonin (8-32) reduced
AKOS024457619
CID 16133792
AC187
151804-77-2
161902-50-7
8-32-Calcitonin (salmonreduced), N-acetyl-30-L-asparagine-32-L-tyrosinamide-
Acetyl-(Asn??00Tyr??)-Calcitonin(8-32)(salmonI)
Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salmon I)
AC-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
ACETYL-VAL-LEU-GLY-LYS-LEU-SER-GLN-GLU-LEU-HIS-LYS-LEU-GLN-THR-TYR-PRO-ARG-THR-ASN-THR-GLY-SER-ASN-THR-TYR-NH2
ACETYL-[ASN30 TYR32]-CALCITONIN FRAGMENT
AC-(ASN30,TYR32)-CALCITONIN (8-32) (SALMON I)
Acetyl-(Asn30,Tyr32)-Calcitonin (8-32) (salMon I) AC187

MDL Number

MFCD03093452

FAQ

What are the physical and chemical properties of Salmon calcitonin (8-32) reduced (CAS: 151804-77-2)?

Salmon calcitonin (8-32) reduced is a peptide with a molecular weight of approximately 1,054 Da. It is a solid with a white or off-white crystalline form. The compound is soluble in water and somewhat less soluble in organic solvents. It exhibits moderate reactivity with basic substances and is stable under neutral conditions. This peptide is typically used in pharmaceutical applications and has a relatively stable nature at room temperature and in aqueous solutions.

How is Salmon calcitonin (8-32) reduced (CAS: 151804-77-2) typically synthesized?

Salmon calcitonin (8-32) reduced is synthesized through solid-phase peptide synthesis. The process involves the stepwise addition of amino acids to a growing peptide chain using a protected amino terminal approach. The N-terminal residue is protected, and the synthesis proceeds from the C-terminus. The final peptide is then cleaved from the resin and deprotected, yielding the reduced form. Commonly used protecting groups include Fmoc and Boc, and the synthesis typically achieves high yields and good purity.

What industries use Salmon calcitonin (8-32) reduced (CAS: 151804-77-2)?

Salmon calcitonin (8-32) reduced is primarily used in the pharmaceutical industry. It serves as an active pharmaceutical ingredient (API) in medications aimed at treating osteoporosis and hypercalcemia. The compound is also of interest in biotechnology and research settings, where it is used for its potential therapeutic benefits and for studying calcium homeostasis mechanisms.

What precautions should be taken when handling Salmon calcitonin (8-32) reduced (CAS: 151804-77-2)?

When handling Salmon calcitonin (8-32) reduced, it is essential to use appropriate personal protective equipment (PPE), including gloves, laboratory coat, and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. Spills should be managed with care, preferably in a fume hood, using absorbent materials and disposing of waste according to local regulations. Always refer to the Safety Data Sheet (SDS) for specific handling instructions and emergency procedures.