N,N'-Desethylene-N,N'-diformyl Levofloxacin | CAS No. 151377-74-1

N,N'-Desethylene-N,N'-diformyl Levofloxacin

Basic Information

CAS Number

151377-74-1

Molecular Formula

C18H18FN3O6

Molecular Weight

391.36 g/mol

AD

Basic Physical Properties

Melting Point

179-181°C

CC1COC2=C3N1C=C(C(=O)C3=CC(=C2N(CCN(C)C=O)C=O)F)C(=O)O

InChI

InChI=1S/C18H18FN3O6/c1-10-7-28-17-14-11(16(25)12(18(26)27)6-22(10)14)5-13(19)15(17)21(9-24)4-3-20(2)8-23/h5-6,8-10H,3-4,7H2,1-2H3,(H,26,27)

InChIKey

HTOKHJLTWLBPPN-UHFFFAOYSA-N

LogP

0.8432000000000002

Topological Polar Surface Area

109.14999999999999 Ų

Hydrogen Bond Donor/Acceptor

1 / 9

Complexity

701

Synonyms & References

English

  • N,N'-Desethylene-N,N'-diforMyl Levofloxacin
  • (S)-9-Fluoro-10-[forMyl[2-(forMylMethylaMino)ethyl]aMino]-2,3-dihydro-3-Methyl-7-oxo-7H-pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic Acid
  • N,N’-Desethylene-N,N’-diformyl Levofloxacin
  • N,N’-DESETHYLENE-N,N’-DIFORMYL LEVOFLOXACIN,TAN SOLID
  • Levofloxacin IMP
  • N,N'-Desethylene-N
  • Levofloxacin impurity
  • (s)-ofloxacin Impurity
  • Levofloxacin DiforMyl IMpurity
  • Levofloxacin Desethylene DiforMyl IMpurity
  • (3S)-9-Fluoro-10-(formyl{2-[formyl(methyl)amino]ethyl}amino)-3-methyl-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
  • (S)-9-Fluoro-3-methyl-10-(N-(2-(N-methylformamido)ethyl)formamido)-7-oxo-3,7-dihydro-2H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid
  • N,N'-Desethylene-N,N'-diformyl Levofloxacin
  • Levofloxacin Diformyl Impurity
  • DTXSID60747525
  • (2S)-7-fluoro-6-[formyl-[2-[formyl(methyl)amino]ethyl]amino]-2-methyl-10-oxo-4-oxa-1-azatricyclo[7.3.1.05,13]trideca-5(13),6,8,11-tetraene-11-carboxylic acid
  • N26U9LD9HM
  • 7H-Pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid, 9-fluoro-10-[formyl[2-(formylmethylamino)ethyl]amino]-2,3-dihydro-3-methyl-7-oxo-, (S)-
  • 151377-74-1
  • (S)-9-fluoro-3-methyl-10-(N-(2-(N-methylformamido)ethyl)formamido)-7-oxo-2,3-dihydro-7H-[1,4]oxazino[2,3,4-ij]quinoline-6-carboxylic acid

FAQ

What are the physical and chemical properties of N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1)?

N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1) is a crystalline solid with a molecular weight of approximately 458.4 g/mol. It is slightly soluble in water and highly soluble in organic solvents like methanol and acetonitrile. Chemically, it is reactive towards nucleophiles and can undergo hydrolysis and reduction under certain conditions.

How is N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1) typically synthesized?

N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1) is typically synthesized by formylation of levofloxacin followed by desethylation. This process involves the use of formic acid and a Lewis acid catalyst in the presence of a suitable solvent. The yield is generally high, and the product can be isolated by recrystallization.

What industries use N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1)?

N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1) is primarily used in the pharmaceutical industry for the development of new fluoroquinolone derivatives. It may also have applications in research for studying drug metabolism and pharmacokinetics.

What precautions should be taken when handling N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1)?

When handling N,N'-Desethylene-N,N'-diformyl Levofloxacin (CAS: 151377-74-1), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a fume hood to minimize exposure. Spills should be cleaned up immediately using appropriate methods, and safety data sheets (SDS) should be consulted for detailed handling procedures and emergency information.

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