Proadrenomedullin (1-20) (human)

Basic Information

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CAS Number

150238-87-2

Molecular Formula

C112H178N36O27

Molecular Weight

2460.8 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

SMILES

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CC(C)CC(C(=O)NC(CO)C(=O)NC(CCCNC(=N)N)C(=O)N)NC(=O)C(C)NC(=O)C(CC1=CNC2=CC=CC=C21)NC(=O)C(CCCCN)NC(=O)C(CC(=O)N)NC(=O)C(CC3=CNC4=CC=CC=C43)NC(=O)C(CCCCN)NC(=O)C(CCCCN)NC(=O)C(CCCNC(=N)N)NC(=O)C(CC5=CC=CC=C5)NC(=O)C(CCC(=O)O)NC(=O)C(CO)NC(=O)C(C)NC(=O)C(C(C)C)NC(=O)C(CC(=O)O)NC(=O)C(CC(C)C)NC(=O)C(CCCNC(=N)N)NC(=O)C(C)N

InChI

InChI=1S/C112H178N36O27/c1-57(2)46-77(102(168)147-85(56-150)107(173)132-70(90(118)156)35-23-43-125-110(119)120)139-92(158)61(8)130-100(166)80(49-64-53-128-68-30-15-13-28-66(64)68)142-97(163)73(34-19-22-42-115)136-105(171)82(51-86(117)151)144-104(170)81(50-65-54-129-69-31-16-14-29-67(65)69)143-96(162)72(33-18-21-41-114)135-94(160)71(32-17-20-40-113)134-95(161)75(37-25-45-127-112(123)124)137-103(169)79(48-63-26-11-10-12-27-63)141-99(165)76(38-39-87(152)153)138-108(174)84(55-149)146-93(159)62(9)131-109(175)89(59(5)6)148-106(172)83(52-88(154)155)145-101(167)78(47-58(3)4)140-98(164)74(133-91(157)60(7)116)36-24-44-126-111(121)122/h10-16,26-31,53-54,57-62,70-85,89,128-129,149-150H,17-25,32-52,55-56,113-116H2,1-9H3,(H2,117,151)(H2,118,156)(H,130,166)(H,131,175)(H,132,173)(H,133,157)(H,134,161)(H,135,160)(H,136,171)(H,137,169)(H,138,174)(H,139,158)(H,140,164)(H,141,165)(H,142,163)(H,143,162)(H,144,170)(H,145,167)(H,146,159)(H,147,168)(H,148,172)(H,152,153)(H,154,155)(H4,119,120,125)(H4,121,122,126)(H4,123,124,127)/t60-,61-,62-,70-,71-,72-,73-,74-,75-,76-,77-,78-,79-,80-,81-,82-,83-,84-,85-,89-/m0/s1

InChIKey

PIRWNASAJNPKHT-SHZATDIYSA-N

LogP

6.08680

Topological Polar Surface Area

1075.5 Å²

Hydrogen Bond Donor/Acceptor

49 / 63

Complexity

5380

Synonyms & References

English

L-Alanyl-L-arginyl-L-leucyl-L-alpha-aspartyl-L-valyl-L-alanyl-L-seryl-L-alpha-glutamyl-L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl-L-argininamide
AKOS034834090
H-ALA-ARG-LEU-ASP-VAL-ALA-SER-GLU-PHE-ARG-LYS-LYS-TRP-ASN-LYS-TRP-ALA-LEU-SER-ARG-NH2
DTXSID40746652
PAMP-20 (human)
150238-87-2
Proadrenomedullin (1-20) (human)
MFCD01076554
S-150238-87-2
Proadrenomedullin(1-20)(human)
PD080403
L-Argininamide,L-alanyl-L-arginyl-L-leucyl-L-a-aspartyl-L-valyl-L-alanyl-L-seryl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl-L-seryl-
L-Argininamide,L-alanyl-L-arginyl-L-leucyl-L-a-aspartyl-L-valyl-L-alanyl-L-seryl-L-a-glutamyl-...
L-Argininamide,L-alanyl-L-arginyl-L-leucyl-L-a-aspartyl-L-valyl-L-alanyl-L-seryl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-lysy
L-Argininamide,L-alanyl-L-arginyl-L-leucyl-L-a-aspartyl-L-valyl-L-alanyl-L-seryl-L-a-glutamyl-L-phenylalanyl-L-arginyl-L-lysyl-L-lysyl-L-tryptophyl-L-asparaginyl-L-lysyl-L-tryptophyl-L-alanyl-L-leucyl
PAMP
Proadrenomedullin Fragment 1-20 human
ALA-ARG-LEU-ASP-VAL-ALA-SER-GLU-PHE-ARG-LYS-LYS-TRP-ASN-LYS-TRP-ALA-LEU-SER-ARG-NH2: ARLDVASEFRKKWNKWALSR-NH2
1-20-Proadrenomedullin (human)
Human PAMP
Human PAMP 20
Human PAMP(1-20)
Proadrenomedullin N-terminal 20 peptide (human)
FTSH1
Meg-4
YME1L1
PAMP (HUMAN)
PRODEPIN, HUMAN
PROAM-N20 (HUMAN)
PAMP (1-20) HUMAN
PRO4304

MDL Number

MFCD01076554

FAQ

What are the physical and chemical properties of Proadrenomedullin (1-20) (human) (CAS: 150238-87-2)?

Proadrenomedullin (1-20) (human) is a polypeptide with a molecular weight of approximately 2479.42 Da. It has a crystalline form that is stable under neutral conditions and is poorly soluble in water. The compound is reactive towards proteases, which can lead to degradation. It is typically stored dry at -20°C and dissolved in appropriate buffers for use in biochemical assays.

How is Proadrenomedullin (1-20) (human) (CAS: 150238-87-2) typically synthesized?

Proadrenomedullin (1-20) (human) is synthesized through solid-phase peptide synthesis using Fmoc chemistry. The synthesis involves stepwise coupling of amino acids and protection/deprotection of the growing peptide chain. Yield and selectivity are typically high, and the final product is purified using HPLC to ensure high purity.

What industries use Proadrenomedullin (1-20) (human) (CAS: 150238-87-2)?

Proadrenomedullin (1-20) (human) is primarily used in the pharmaceutical industry for its potential in cardiovascular and neurohormonal research. It also has applications in the development of diagnostic tools for cardiovascular diseases and as a research tool in molecular biology and biochemistry.

What precautions should be taken when handling Proadrenomedullin (1-20) (human) (CAS: 150238-87-2)?

When handling Proadrenomedullin (1-20) (human), it is recommended to wear appropriate personal protective equipment (PPE) including gloves, lab coat, and goggles. The compound should be stored in a cool, dry place away from direct sunlight. Spills should be handled in a well-ventilated area using appropriate absorbent materials. Always consult the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.