2,4-Difluorobenzenesulfonyl chloride

Basic Information

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CAS Number

13918-92-8

Molecular Formula

C6H3ClF2O2S

Molecular Weight

212.6 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

84°C/3mmHg

Refractive Index

n20/D 1.518(lit.)

SMILES

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C1=CC(=C(C=C1F)F)S(=O)(=O)Cl

InChI

InChI=1S/C6H3ClF2O2S/c7-12(10,11)6-2-1-4(8)3-5(6)9/h1-3H

InChIKey

FJSAJUXIHJIAMD-UHFFFAOYSA-N

LogP

1.8922999999999999

Topological Polar Surface Area

34.14 Å²

Hydrogen Bond Donor/Acceptor

0 / 2

Complexity

249

Safety Information

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Hazard Statement

H290 May be corrosive to metals
Corrosive to Metals

H314 Causes severe skin burns and eye damage
Skin corrosion/irritation

Hazard Class

Class 8 Class 8

Sensitiveness

Moisture Sensitive

Synonyms & References

English

2,4-difluoro benzenesulfonyl chloride
Z94601182
2,4-Difluorobenzene-1-SulfonylChloride
AKOS000309831
InChI=1/C6H3ClF2O2S/c7-12(10,11)6-2-1-4(8)3-5(6)9/h1-3H
EN300-01724
FT-0610086
2,4-difluoro benzene sulfonyl chloride
Benzenesulfonyl chloride, 2,4-difluoro-
CS-W020088
SCHEMBL113810
2,4-Difluorobenzenesulfonyl chloride
D2939
DTXSID20370191
AM97551
2,4-di-fluorobenzenesulphonyl chloride
F1967-0135
MFCD00042481
2,4-DIFLUOROBENZENESULPHONYLCHLORIDE
2,4-Difluorobenzenesulfonyl chloride, 97%
A807496
2,4-Difluorobenzene-1-Sulfonyl Chloride
2,4-difluorophenylsulfonyl chloride
PS-10899
2,4-bis(fluoranyl)benzenesulfonyl chloride
2,4-difluoro-benzenesulfonyl chloride
2,4-difluorobenzene sulfonyl chloride
13918-92-8
J-507209
FJSAJUXIHJIAMD-UHFFFAOYSA-
2,4-difluorobenzenesulfonylchloride

MDL Number

MFCD00042481

Customs Code

2904909090

FAQ

What are the physical and chemical properties of 2,4-Difluorobenzenesulfonyl chloride (CAS: 13918-92-8)?

2,4-Difluorobenzenesulfonyl chloride is a white crystalline solid with a molecular weight of approximately 215.06 g/mol. It has a low solubility in water but is more soluble in polar organic solvents like DMF and DMSO. Reactively, it is a strong electrophile, forming stable esters and amides. It is highly reactive towards nucleophiles and can participate in electrophilic aromatic substitution reactions.

How is 2,4-Difluorobenzenesulfonyl chloride (CAS: 13918-92-8) typically synthesized?

2,4-Difluorobenzenesulfonyl chloride can be synthesized via the chlorosulfonylation of 2,4-difluorobenzenesulfonic acid. This process is catalyzed by thionyl chloride in the presence of a solvent like toluene. The reaction is carried out under reflux conditions, yielding a high yield of the target compound.

What industries use 2,4-Difluorobenzenesulfonyl chloride (CAS: 13918-92-8)?

2,4-Difluorobenzenesulfonyl chloride is primarily used in the pharmaceutical industry, where it serves as an intermediate in the synthesis of various bioactive compounds. It is also utilized in the polymer industry for modifying polymer properties, and in the sensor industry for developing gas-detecting sensors due to its reactivity.

What precautions should be taken when handling 2,4-Difluorobenzenesulfonyl chloride (CAS: 13918-92-8)?

2,4-Difluorobenzenesulfonyl chloride is corrosive and requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or under a fume hood to prevent inhalation. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.