2,4-Difluorobenzenesulfonyl chloride(CAS: 13918-92-8)

2,4-Difluorobenzenesulfonyl chloride is a white crystalline solid with a molecular weight of approximately 215.06 g/mol. It has a low solubility in water but is more soluble in polar organic solvents like DMF and DMSO. Reactively, it is a strong electrophile, forming stable esters and amides. It is highly reactive towards nucleophiles and can participate in electrophilic aromatic substitution reactions.

2,4-Difluorobenzenesulfonyl chloride can be synthesized via the chlorosulfonylation of 2,4-difluorobenzenesulfonic acid. This process is catalyzed by thionyl chloride in the presence of a solvent like toluene. The reaction is carried out under reflux conditions, yielding a high yield of the target compound.

2,4-Difluorobenzenesulfonyl chloride is primarily used in the pharmaceutical industry, where it serves as an intermediate in the synthesis of various bioactive compounds. It is also utilized in the polymer industry for modifying polymer properties, and in the sensor industry for developing gas-detecting sensors due to its reactivity.

2,4-Difluorobenzenesulfonyl chloride is corrosive and requires the use of personal protective equipment (PPE) such as gloves, goggles, and a lab coat. It should be handled in a well-ventilated area or under a fume hood to prevent inhalation. Spills should be cleaned up immediately using appropriate absorbents, and the area should be flushed with water. Always refer to the Safety Data Sheet (SDS) for detailed handling and emergency procedures.