(S)-3-(4-Bromophenyl)piperidine

Basic Information

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CAS Number

1335523-82-4

Molecular Formula

C11H14BrN

Molecular Weight

240.14 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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Brc1ccc(cc1)[C@@H]1CCCNC1

LogP

2.9161

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Synonyms & References

English

Piperidine, 3-(4-bromophenyl)-,(3S)
Not available
(3S)-3-(4-bromophenyl)piperidine

MDL Number

MFCD20451701

FAQ

What are the physical and chemical properties of (S)-3-(4-Bromophenyl)piperidine (CAS: 1335523-82-4)?

(S)-3-(4-Bromophenyl)piperidine is a white crystalline solid with a molecular weight of 262.02 g/mol. It has a low solubility in water but is soluble in organic solvents like methanol and acetonitrile. The compound reacts readily with nucleophiles and is stable under acidic and basic conditions. It is also known for its high reactivity towards electrophilic substitution at the bromophenyl group.

How is (S)-3-(4-Bromophenyl)piperidine (CAS: 1335523-82-4) typically synthesized?

(S)-3-(4-Bromophenyl)piperidine is typically synthesized via the condensation of 4-bromophenylacetic acid with piperidine, followed by reduction. The reaction is catalyzed by palladium(II) acetate and triphenylphosphine, with good regioselectivity and yield. The process is optimized for high purity and stereoselectivity, making it suitable for pharmaceutical applications.

What industries use (S)-3-(4-Bromophenyl)piperidine (CAS: 1335523-82-4)?

(S)-3-(4-Bromophenyl)piperidine is primarily used in the pharmaceutical industry for the development of novel drugs. It is also explored in the polymer industry for the production of advanced materials with specific properties. Additionally, its potential applications in sensor technology and semiconductor manufacturing are being investigated due to its unique chemical structure and reactivity.

What precautions should be taken when handling (S)-3-(4-Bromophenyl)piperidine (CAS: 1335523-82-4)?

When handling (S)-3-(4-Bromophenyl)piperidine, it is essential to use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work in a well-ventilated area or fume hood to minimize inhalation risks. Ensure proper storage in a cool, dry place away from direct sunlight. In case of a spill, use appropriate containment and clean up with care, referring to the safety data sheet (SDS) for specific instructions. Always follow safety guidelines and consult with a safety professional if needed.