7-Chloro-4-quinolinecarboxylic acid

Basic Information

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CAS Number

13337-66-1

Molecular Formula

C10H6ClNO2

Molecular Weight

207.62 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Boiling Point

382.1℃ at 760 mmHg

SMILES

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C1=CC2=C(C=CN=C2C=C1Cl)C(=O)O

InChI

InChI=1S/C10H6ClNO2/c11-6-1-2-7-8(10(13)14)3-4-12-9(7)5-6/h1-5H,(H,13,14)

InChIKey

TXYVRYRRTQYTHJ-UHFFFAOYSA-N

LogP

2.586400000000001

Topological Polar Surface Area

50.19 Å²

Hydrogen Bond Donor/Acceptor

1 / 3

Complexity

234

Synonyms & References

English

7-Chloroquinoline-4-carboxylicacid
7-Chloro-4-quinolinecarboxylic acid
AKOS015851202
FT-0645785
7-chloro-quinoline-4-carboxylic acid
MFCD00034451
4-Quinolinecarboxylic acid, 7-chloro-
AMY26411
7-Chlorocinchoninic acid
DTXSID50346167
13337-66-1
SCHEMBL5762904
CS-0086785
AS-41348
Z1269240013
A850370
SY128758
7-chloroquinoline-4-carboxylic acid, 99%
EN300-704006
7-chloroquinoline-4-carboxylic acid
SB70186
7-Chloro-4-quinolinecarboxylic acid #
7-Chloroquinoline-4-carboxylic acid
4-Quinolinecarboxylicacid, 7-chloro-
7-Chlor-chinolin-4-carbonsaeure

MDL Number

MFCD00034451

Customs Code

2933499090

FAQ

What are the physical and chemical properties of 7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1)?

7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1) is a crystalline solid with a molecular weight of approximately 215.65 g/mol. It has a pKa of about 4.7 and is slightly soluble in water. The compound is known for its high reactivity, particularly in electrophilic aromatic substitution reactions.

How is 7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1) typically synthesized?

7-Chloro-4-quinolinecarboxylic acid is typically synthesized by the chlorination of 4-quinolinecarboxylic acid, followed by hydrolysis of the alkylated product. Common reagents include thionyl chloride or phosphorus oxychloride, and the reaction is usually performed under anhydrous conditions to improve yield.

What industries use 7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1)?

7-Chloro-4-quinolinecarboxylic acid finds applications in the pharmaceutical industry, where it is used as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for the development of functional materials and in the sensor industry for the fabrication of gas sensors.

What precautions should be taken when handling 7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1)?

Handling 7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1) requires the use of proper personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from moisture and strong oxidizers. In case of a spill, it is recommended to use a fume hood and follow standard safety procedures for chemical spills. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.