7-Chloro-4-quinolinecarboxylic acid(CAS: 13337-66-1)

7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1) is a crystalline solid with a molecular weight of approximately 215.65 g/mol. It has a pKa of about 4.7 and is slightly soluble in water. The compound is known for its high reactivity, particularly in electrophilic aromatic substitution reactions.

7-Chloro-4-quinolinecarboxylic acid is typically synthesized by the chlorination of 4-quinolinecarboxylic acid, followed by hydrolysis of the alkylated product. Common reagents include thionyl chloride or phosphorus oxychloride, and the reaction is usually performed under anhydrous conditions to improve yield.

7-Chloro-4-quinolinecarboxylic acid finds applications in the pharmaceutical industry, where it is used as an intermediate in the synthesis of various drugs. It is also utilized in the polymer industry for the development of functional materials and in the sensor industry for the fabrication of gas sensors.

Handling 7-Chloro-4-quinolinecarboxylic acid (CAS: 13337-66-1) requires the use of proper personal protective equipment (PPE), including gloves, safety goggles, and a lab coat. It should be stored in a cool, dry place away from moisture and strong oxidizers. In case of a spill, it is recommended to use a fume hood and follow standard safety procedures for chemical spills. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.