Phenyl 4-amino-2-hydroxybenzoate

Basic Information

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CAS Number

133-11-9

Molecular Formula

C13H11NO3

Molecular Weight

229.24 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Esters

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Amines

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Basic Physical Properties

Melting Point

147-152 ºC

Boiling Point

371.13°C (rough estimate)

Refractive Index

1.5500 (estimate)

SMILES

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C1=CC=C(C=C1)OC(=O)C2=C(C=C(C=C2)N)O

InChI

InChI=1S/C13H11NO3/c14-9-6-7-11(12(15)8-9)13(16)17-10-4-2-1-3-5-10/h1-8,15H,14H2

InChIKey

DNVVZWSVACQWJE-UHFFFAOYSA-N

LogP

2.1936

Topological Polar Surface Area

72.55000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

263

Synonyms & References

English

D05460
phenyl-aminosalicylate
F19835
Pheny-Pas-Tebamin (TN)
Tox21_111538
SR-01000363421
FENAMISAL [MART.]
Spectrum5_001125
Fenamisalum [INN-Latin]
CHEMBL1200868
Spectrum2_000439
SPBio_000458
Fenamisalum (INN-Latin)
Tebanyl
KBioGR_001273
Salicylic acid, 4-amino-, phenyl ester
Salicyclic acid, phenyl ester
KBio2_004377
HMS2091C03
KBioSS_001809
Phenyl p-aminosalicylate
BRD-K73157543-001-02-5
Fenamisal; NSC 40144; PAS-Tebamin
KBio1_001932
SPECTRUM305025
CHEBI:114203
SpecPlus_000892
SR-01000363421-2
Spectrum_001329
FR 7
Phenyl 4-aminosalicylate

MDL Number

MFCD00007788

Customs Code

2922509090

FAQ

What are the physical and chemical properties of Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9)?

Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9) is a white to off-white crystalline solid with a molecular weight of approximately 252.25 g/mol. It has a solubility of 1.5 g/L in water at 20°C. Chemically, it is slightly basic and exhibits weak reactivity in acidic conditions. It is soluble in common organic solvents like ethanol and acetone.

How is Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9) typically synthesized?

Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9) is typically synthesized via a condensation reaction between 4-amino-2-hydroxybenzoic acid and phenol. The reaction is catalyzed by a Lewis acid like aluminum chloride and usually proceeds with high yield. The product is then purified by recrystallization from hot water or ethanol.

What industries use Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9)?

Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9) is primarily used in the pharmaceutical industry as an intermediate in the synthesis of various drugs. It is also used in polymer production as a stabilizer and in the development of sensors and semiconductors for electronic applications.

What precautions should be taken when handling Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9)?

When handling Phenyl 4-amino-2-hydroxybenzoate (CAS: 133-11-9), appropriate personal protective equipment (PPE) such as gloves and goggles should be worn. It should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, they should be cleaned up using absorbent materials and disposed of according to local regulations. Always refer to the Safety Data Sheet (SDS) for detailed handling and safety information.