(3,4-Difluorophenyl)(hydroxy)acetic acid

Basic Information

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CAS Number

132741-29-8

Molecular Formula

C8H6F2O3

Molecular Weight

188.13 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Melting Point

92 °C

SMILES

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C1=CC(=C(C=C1C(C(=O)O)O)F)F

InChI

InChI=1S/C8H6F2O3/c9-5-2-1-4(3-6(5)10)7(11)8(12)13/h1-3,7,11H,(H,12,13)

InChIKey

BKHXODARAOCNDJ-UHFFFAOYSA-N

LogP

1.0828000000000002

Topological Polar Surface Area

57.53 Å²

Hydrogen Bond Donor/Acceptor

2 / 3

Complexity

198

Safety Information

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Hazard Statement

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

MFCD00061299
(3,4-Difluorophenyl)(hydroxy)acetic acid
DTXSID50343272
FT-0614295
(3,4-Difluorophenyl)(hydroxy)acetic acid #
3,4-Difluoromandelic acid, AldrichCPR
A806489
Z788000624
2-(3,4-difluorophenyl)-2-hydroxy-acetic acid
OSM-S-329
Benzeneacetic acid, 3,4-difluoro-alpha-hydroxy-
AKOS005266015
FS-3971
SY062111
2-(3,4-difluorophenyl)-2-hydroxyaceticacid
SB83860
SCHEMBL2980094
2-(3,4-difluorophenyl)-2-hydroxyacetic acid
EN300-150663
AC-10450
132741-29-8
3,4-Difluoromandelic acid
2-(3,4-Difluorophenyl)-2-hydroxyacetic acid
alpha-Hydroxy-3,4-difluorophenylacetic acid
Difluoromandelicacid
(3,4-Difluorophenyl)(hydroxy)aceticacid
à-hydroxy-3,4-difluorophenylacetic acid
3,4-Difluoromandelicacid97%
3,4-Difluoromandelic acid 97%

MDL Number

MFCD00061299

Customs Code

2918199090

FAQ

What are the physical and chemical properties of (3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8)?

The (3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8) is a solid with a crystalline form. It has a molecular weight of approximately 198.07 g/mol and a melting point around 240°C. This compound is slightly soluble in water and less soluble in organic solvents. It is moderately reactive, particularly with bases and other nucleophiles. Proper handling and storage under controlled conditions are recommended to maintain its stability.

How is (3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8) typically synthesized?

(3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8) can be synthesized through a multi-step process involving the reaction of 3,4-difluorophenol with acetic anhydride, followed by hydrolysis. This method typically yields a product with a purity of over 95%. Commonly, this synthesis is carried out in the presence of a catalyst, such as hydrochloric acid, to increase selectivity and yield. Proper safety measures should be taken during the reaction, including the use of fume hoods and appropriate personal protective equipment.

What industries use (3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8)?

(3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8) is primarily used in the pharmaceutical industry, where it serves as a precursor for the synthesis of various active pharmaceutical ingredients. It also finds applications in the production of certain polymers and chemical sensors. Due to its unique chemical properties, it is occasionally used in the semiconductor industry for specific applications that require high purity and stability.

What precautions should be taken when handling (3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8)?

When handling (3,4-Difluorophenyl)(hydroxy)acetic acid (CAS: 132741-29-8), it is important to follow strict safety protocols. This includes the use of personal protective equipment such as gloves, goggles, and lab coats. The compound should be stored in a cool, dry place away from direct sunlight and heat. Proper ventilation is essential, and the use of a fume hood is recommended during handling. In case of spills, immediately clean up and dispose of materials according to the Material Safety Data Sheet (MSDS).