![2-Methyl-2-propanyl [1-(4-chlorophenyl)cyclobutyl]carbamate structure](https://static.chemtradehub.com/structs/103/1032349-96-4-11ab.webp "2-Methyl-2-propanyl [1-(4-chlorophenyl)cyclobutyl]carbamate structure")
2-Methyl-2-propanyl [1-(4-chlorophenyl)cyclobutyl]carbamate
CAS Number:
1032349-96-4
Molecular Formula:
C15H20ClNO2
2-Methyl-2-propanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate | CAS No. 1289387-44-5
2-Methyl-2-propanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate
Basic Information
CAS Number
1289387-44-5
Molecular Formula
C13H24N2O2
Molecular Weight
240.35 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 2-CYCLOPROPYLAMINOMETHYL-PYRROLIDINE-1-CARBOXYLIC ACID TERT-BUTYL ESTER
- tert-butyl 2-((cyclopropylamino)methyl)pyrrolidine-1-carboxylate
- tert-butyl 2-[(cyclopropylamino)methyl]pyrrolidine-1-carboxylate
MDL Number
MFCD18837102
FAQ
What are the physical and chemical properties of 2-Methyl-2-propanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate (CAS: 1289387-44-5)?
2-Methyl-2-propanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate is a white or off-white crystalline solid with a molecular weight of approximately 288.4 g/mol. It has a pKa of around 6.5, indicating basicity. The compound is poorly soluble in water but soluble in organic solvents such as ethanol and acetone. It exhibits moderate reactivity in nucleophilic substitution reactions and can be used as a chiral building block in organic synthesis.
How is 2-Methyl-2-propanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate (CAS: 1289387-44-5) typically synthesized?
2-Methyl-2-propanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate is typically synthesized via a multi-step reaction involving the coupling of 2-cyclopropylaminomethyl-1-pyrrolidinecarboxylic acid with 2-methyl-2-propanol. The reaction is catalyzed by a transition metal complex, such as palladium(II) acetate, in the presence of a base like triethylamine. High yields are achieved with excellent regioselectivity and enantioselectivity under optimized reaction conditions.
What industries use 2-Methyl-2-proanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate (CAS: 1289387-44-5)?
2-Methyl-2-proanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate is primarily used in the pharmaceutical and fine chemical industries as a chiral building block. It serves as an intermediate in the synthesis of various chiral compounds, which are essential for drug development. Additionally, it finds applications in the production of chiral resolving agents and in the development of new chiral ligands for asymmetric catalysis.
What precautions should be taken when handling 2-Methyl-2-proanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate (CAS: 1289387-44-5)?
When handling 2-Methyl-2-proanyl 2-[(cyclopropylamino)methyl]-1-pyrrolidinecarboxylate, it is important to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The substance should be stored in a cool, dry place, away from heat sources and direct sunlight. In case of spills, handle them with care and use appropriate spill cleanup procedures as outlined in the Material Safety Data Sheet (MSDS). Always ensure adequate ventilation, preferably in a fume hood, during handling and synthesis to avoid inhalation of vapors.
Related Compounds
![4-Hydrazino-5-phenylthieno[2,3-d]pyrimidine structure](https://static.chemtradehub.com/structs/113/113246-86-9-b802.webp "4-Hydrazino-5-phenylthieno[2,3-d]pyrimidine structure")
![5-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-fluorobenzaldehyde structure](https://static.chemtradehub.com/structs/113/113984-67-1-936e.webp "5-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-fluorobenzaldehyde structure")
5-{[Dimethyl(2-methyl-2-propanyl)silyl]oxy}-2-fluorobenzaldehyde
CAS Number:
113984-67-1
Molecular Formula:
C13H19FO2Si
![Ethyl 1H-pyrazolo[3,4-B]pyridine-5-carboxylate structure](https://static.chemtradehub.com/structs/125/1256824-48-2-82de.webp "Ethyl 1H-pyrazolo[3,4-B]pyridine-5-carboxylate structure")
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