(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol

Basic Information

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CAS Number

127852-24-8

Molecular Formula

C9H9F3O

Molecular Weight

190.16 g/mol

Chemical Classification

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

206.9°C at 760 mmHg

Density

1.234

Flash Point

96.1°C

Refractive Index

1.461

SMILES

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CC(C1=CC(=CC=C1)C(F)(F)F)O

InChI

InChI=1S/C9H9F3O/c1-6(13)7-3-2-4-8(5-7)9(10,11)12/h2-6,13H,1H3/t6-/m1/s1

InChIKey

YNVXCOKNHXMBQC-ZCFIWIBFSA-N

LogP

2.7587000000000015

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

167

Safety Information

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Hazard Statement

Synonyms & References

English

A805757
AKOS017343700
BENZENEMETHANOL, A-METHYL-3-(TRIFLUOROMETHYL)-, (AR)-
Benzenemethanol, alpha-methyl-3-(trifluoromethyl)-, (alphaR)-
(R)-1-[3-(trifluoromethyl)phenyl]ethanol
SCHEMBL343403
EN300-56942
J-005548
CS-15950
(1R)-1-[3-(Trifluoromethyl)phenyl]ethan-1-ol
D72011
(R)-1-(3-(trifluoromethyl)phenyl)ethanol
(alphaR)-alpha-Methyl-3-(trifluoromethyl)benzenemethanol
CS-0077597
127852-24-8
DTXSID801238620
(1R)-1-[3-(trifluoromethyl)phenyl]ethanol
CFA85224
MFCD02684188
Benzenemethanol, a-methyl-3-(trifluoromethyl)-, (aR)-
(αR)-α-Methyl-3-(trifluoromethyl)-benzenemethanol
(R)-1-[3-(TRIFLUOROMETHYL)PHENYL]ETHANOL
R-MTF-PEL
(R)-1-(3-Trifluoromethylphenyl)ethanol
(alphaR)-3-Trifluoromethyl-alpha-methylbenzenemethanol
(αR)-α-Methyl-3-(trifluoromethyl)-benzenemethanol,99%e.e.

MDL Number

MFCD02684188

FAQ

What are the physical and chemical properties of (1R)-1-[3-(Trifluoromethyl)phenyl]ethanol (CAS: 127852-24-8)?

(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol is a colorless liquid with a molecular weight of approximately 250.14 g/mol. It has a boiling point of 98.5°C and a density of 1.23 g/cm³. This compound is poorly soluble in water but is miscible with most organic solvents. It exhibits moderate reactivity, particularly towards nucleophiles, and can undergo substitution reactions. Its physical properties make it suitable for various applications in organic synthesis and pharmaceuticals.

How is (1R)-1-[3-(Trifluoromethyl)phenyl]ethanol (CAS: 127852-24-8) typically synthesized?

(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol is typically synthesized via a Friedel-Crafts alkylation reaction where ethyl trifluoromethylbenzene is reacted with an alcohol in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction provides good yield and selectivity, making it a common method for this compound's preparation.

What industries use (1R)-1-[3-(Trifluoromethyl)phenyl]ethanol (CAS: 127852-24-8)?

(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol is primarily used in the pharmaceutical industry for the synthesis of drug intermediates and in the polymer industry for the development of advanced materials. It also finds applications in the production of sensors and as a reagent in organic synthesis due to its unique trifluoromethyl substituent.

What precautions should be taken when handling (1R)-1-[3-(Trifluoromethyl)phenyl]ethanol (CAS: 127852-24-8)?

When handling (1R)-1-[3-(Trifluoromethyl)phenyl]ethanol, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be contained and cleaned up with appropriate solvents. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.