(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol(CAS: 127852-24-8)

(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol is a colorless liquid with a molecular weight of approximately 250.14 g/mol. It has a boiling point of 98.5°C and a density of 1.23 g/cm³. This compound is poorly soluble in water but is miscible with most organic solvents. It exhibits moderate reactivity, particularly towards nucleophiles, and can undergo substitution reactions. Its physical properties make it suitable for various applications in organic synthesis and pharmaceuticals.

(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol is typically synthesized via a Friedel-Crafts alkylation reaction where ethyl trifluoromethylbenzene is reacted with an alcohol in the presence of a Lewis acid catalyst such as aluminum trichloride. The reaction provides good yield and selectivity, making it a common method for this compound's preparation.

(1R)-1-[3-(Trifluoromethyl)phenyl]ethanol is primarily used in the pharmaceutical industry for the synthesis of drug intermediates and in the polymer industry for the development of advanced materials. It also finds applications in the production of sensors and as a reagent in organic synthesis due to its unique trifluoromethyl substituent.

When handling (1R)-1-[3-(Trifluoromethyl)phenyl]ethanol, it is important to wear appropriate personal protective equipment (PPE), including gloves and safety goggles. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risk. Spills should be contained and cleaned up with appropriate solvents. Always refer to the Safety Data Sheet (SDS) for detailed safety information and emergency procedures.