Ciprofloxacin-d8, Hydrochloride

Basic Information

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CAS Number

1216659-54-9

Molecular Formula

C17H11D8ClFN3O3

Molecular Weight

375.86 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

SMILES

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C1CC1N2C=C(C(=O)C3=CC(=C(C=C32)N4CCNCC4)F)C(=O)O.Cl

InChI

InChI=1S/C17H18FN3O3.ClH/c18-13-7-11-14(8-15(13)20-5-3-19-4-6-20)21(10-1-2-10)9-12(16(11)22)17(23)24;/h7-10,19H,1-6H2,(H,23,24);1H/i3D2,4D2,5D2,6D2;

InChIKey

DIOIOSKKIYDRIQ-JCYLEXHWSA-N

LogP

2.0051

Topological Polar Surface Area

74.57 Å²

Hydrogen Bond Donor/Acceptor

2 / 6

Complexity

571

Synonyms & References

English

Ciprofloxacin-d8?HCl (piperazine-d8)
Ciprofloxacin-d8 Hydrochloride
1-cyclopropyl-6-fluoro-7-(2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid,hydrochloride
Ciprofloxacin hydrochloride-d8hydrate
Ciprofloxacin-d8 hydrochloride hydrate
Ciprofloxacin-d8 (hydrochloride)
Ciprofloxacin-d
1-Cyclopropyl-6-fluoro-7-(2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid hydrochloride; Ciprofloxacin D8 Hydrochloride (piperazine D8)
AKOS030243131
CS-0202022
Ciprofloxacin-D8 hydrochloride hydrate (see Data Sheet)
Ciprofloxacin-D8 HCl
J-004574
DTXSID20678689
G13524
1ST5705A
HY-B0356S
1-Cyclopropyl-6-fluoro-4-oxo-7-[(2,2,3,3,5,5,6,6-~2~H_8_)piperazin-1-yl]-1,4-dihydroquinoline-3-carboxylic acid--hydrogen chloride (1/1)
1-cyclopropyl-6-fluoro-7-(2,2,3,3,5,5,6,6-octadeuteriopiperazin-1-yl)-4-oxoquinoline-3-carboxylic acid;hydrochloride
1216659-54-9
Ciprofloxacin-d8, Hydrochloride
1-CYCLOPROPYL-6-FLUORO-4-OXO-7-[(2,2,3,3,5,5,6,6-(2)H?)PIPERAZIN-1-YL]QUINOLINE-3-CARBOXYLIC ACID HYDROCHLORIDE
Ciprofloxacin-d8 HCl H2O (piperazine-d8)
Ciprofloxacin D8 Hydrochloride
Ciprofloxacin D8 hydrochloride 100 microg/mL in Water
ES-2558
NS00114266

MDL Number

MFCD11101398

FAQ

What are the physical and chemical properties of Ciprofloxacin-d8 hydrochloride (CAS: 1216659-54-9)?

Ciprofloxacin-d8 hydrochloride is a crystalline compound with a molecular weight of approximately 629.8 g/mol. It has a solubility of about 67 mg/mL in water and is stable in a wide pH range. This compound is less reactive compared to its parent compound, ciprofloxacin, and is often used in pharmaceutical applications due to its enhanced stability.

How is ciprofloxacin-d8 hydrochloride (CAS: 1216659-54-9) typically synthesized?

Ciprofloxacin-d8 hydrochloride is typically synthesized by alkylation of the amine group of ciprofloxacin with deuterated alkyl halide, followed by addition of hydrochloric acid. The reaction is catalyzed by a phase-transfer catalyst, and the product is obtained with good yield and selectivity.

What industries use ciprofloxacin-d8 hydrochloride (CAS: 1216659-54-9)?

Ciprofloxacin-d8 hydrochloride is primarily used in the pharmaceutical industry for the synthesis of deuterium-labeled ciprofloxacin for drug metabolism studies. It is also used in research for its enhanced stability and improved labeling efficiency.

What precautions should be taken when handling ciprofloxacin-d8 hydrochloride (CAS: 1216659-54-9)?

When handling ciprofloxacin-d8 hydrochloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbents and the area should be neutralized according to the Safety Data Sheet (SDS).