Ciprofloxacin-d8, Hydrochloride(CAS: 1216659-54-9)

Ciprofloxacin-d8 hydrochloride is a crystalline compound with a molecular weight of approximately 629.8 g/mol. It has a solubility of about 67 mg/mL in water and is stable in a wide pH range. This compound is less reactive compared to its parent compound, ciprofloxacin, and is often used in pharmaceutical applications due to its enhanced stability.

Ciprofloxacin-d8 hydrochloride is typically synthesized by alkylation of the amine group of ciprofloxacin with deuterated alkyl halide, followed by addition of hydrochloric acid. The reaction is catalyzed by a phase-transfer catalyst, and the product is obtained with good yield and selectivity.

Ciprofloxacin-d8 hydrochloride is primarily used in the pharmaceutical industry for the synthesis of deuterium-labeled ciprofloxacin for drug metabolism studies. It is also used in research for its enhanced stability and improved labeling efficiency.

When handling ciprofloxacin-d8 hydrochloride, appropriate personal protective equipment (PPE) such as gloves, goggles, and lab coat should be worn. Work should be conducted in a well-ventilated area or fume hood. Spills should be cleaned up immediately using appropriate absorbents and the area should be neutralized according to the Safety Data Sheet (SDS).