5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid | CAS No. 1204298-65-6
5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
Basic Information
CAS Number
1204298-65-6
Molecular Formula
C6H6F2N2O2
Molecular Weight
176.12 g/mol
AD
Chemical Classification
Basic Physical Properties
Safety Information
View Safety InformationHazard Statement
H315
Causes skin irritation
Skin corrosion/irritation
Skin corrosion/irritation
H319
Causes serious eye irritation
Serious eye damage/eye irritation
Serious eye damage/eye irritation
H335
May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation
Synonyms & References
English
- 5-(Difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
- 5-(difluoromethyl)-1-methylpyrazole-4-carboxylic acid
- BOC-ASP(OFM)-OH
- 1H-Pyrazole-4-carboxylic acid, 5-(difluoromethyl)-1-methyl-
- 1-Methyl-5-(difluoromethyl)-1H-pyrazole-4-carboxylic acid
- 5-Difluoromethyl-1-methyl-1H-pyrazole-4-carboxylic acid
- CTTXMUZEFPPHGD-UHFFFAOYSA-N
- 3543AA
- TRA0070880
- SB21897
- RP23761
- AK123281
- AB0060261
- ST24044238
- 5-difluoromethyl-1-methylpyrazole-4-carboxylic acid
- 5-(difluoromethyl)
- 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid
- DTXSID60679099
- EN300-66591
- CS-W007116
- Z1033285290
- DS-6922
- DB-349657
- 5-difluoromethyl-1-methyl-1h-pyrazole-4-carboxylic acid
- AKOS012187968
- SCHEMBL713246
- 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylicacid
- AC-28859
- J-516337
- STL584006
- MFCD12827721
MDL Number
MFCD12827721
FAQ
What are the physical and chemical properties of 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (CAS: 1204298-65-6)?
5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is a crystalline solid with a molecular weight of approximately 213.03 g/mol. It has a low solubility in water but is more soluble in organic solvents like methanol and acetonitrile. The compound exhibits moderate acidity and can form hydrogen bonds, making it susceptible to hydrolysis under basic conditions. It is also reactive towards nucleophiles and can undergo electrophilic aromatic substitution reactions.
How is 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (CAS: 1204298-65-6) typically synthesized?
5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is typically synthesized through a multi-step process involving the protected pyrazole formation and subsequent deprotection. Common methods include the use of acid chlorides and Grignard reagents. The yield is generally around 70-80%, and the reaction involves the use of anhydrous conditions and appropriate catalysts to enhance selectivity and reaction rate.
What industries use 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (CAS: 1204298-65-6)?
5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid is used in pharmaceuticals for the development of novel drug candidates due to its potential biological activity. It also finds applications in the synthesis of polymer precursors and as a building block in the development of sensors and semiconductors. Its unique chemical properties make it suitable for various research and industrial applications.
What precautions should be taken when handling 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid (CAS: 1204298-65-6)?
When handling 5-(difluoromethyl)-1-methyl-1H-pyrazole-4-carboxylic acid, it is essential to use personal protective equipment (PPE) such as gloves and safety goggles. The compound should be stored in a cool, dry place away from direct sunlight. In case of spillage, it should be handled with caution, ensuring the use of a fume hood. Always refer to the Safety Data Sheet (SDS) for detailed information on handling and disposal procedures.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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