Combretastatin A4

Basic Information

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CAS Number

117048-59-6

Molecular Formula

C18H20O5

Molecular Weight

316.35 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Fine Chemicals Dyes and Pigments Organic Dyes

Basic Physical Properties

Melting Point

81.0 to 85.0 deg-C

Boiling Point

490.3 °C at 760 mmHg

Density

1.184

Flash Point

250.3 °C

Solubility

DMSO: >10mg/mL

Refractive Index

1.607

SMILES

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COC1=C(C=C(C=C1)C=CC2=CC(=C(C(=C2)OC)OC)OC)O

InChI

InChI=1S/C18H20O5/c1-20-15-8-7-12(9-14(15)19)5-6-13-10-16(21-2)18(23-4)17(11-13)22-3/h5-11,19H,1-4H3/b6-5-

InChIKey

HVXBOLULGPECHP-WAYWQWQTSA-N

LogP

3.5970000000000035

pKa

9.65±0.10(Predicted)

Topological Polar Surface Area

57.150000000000006 Å²

Hydrogen Bond Donor/Acceptor

1 / 5

Complexity

358

Safety Information

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Hazard Statement

H318 Causes serious eye damage
Serious eye damage/eye irritation

Hazard Class

Class 6.1 Class 6.1

Storage Conditions

-20℃

Sensitiveness

light-sensitive

Synonyms & References

English

DTXSID101025983
CHEBI:181391
HY-N2146
DS-5860
2'-deoxycombretastatin A1
117048-59-6
UNII-16U6OP69RQ
(Z)-5-(3,4,5-trimethoxystyryl)-2-methoxyphenol
SR-01000946784
Phenol, 2-methoxy-5-(2-(3,4,5-trimethoxyphenyl)ethenyl)-, (Z)-
CCG-265026
C20268
Combrestatin A-4
HMS3650G11
Combretastatin 4
2-Methoxy-5-[(Z)-2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol
CA 4
(combretastatin A-4)2-Methoxy-5-[2-(3,4,5-trimethoxy-phenyl)-vinyl]-phenol
combretastatin A-4, (CSA4)
(Z)-2-METHOXY-5-(3,4,5-TRIMETHOXYSTYRYL)PHENOL
2-methoxy-5-[(Z)-2-(3,4,5-trimethoxyphenyl)vinyl]phenol
NS00116331
DB14680
AMY24892
5-[(S)-2-Hydroxy-2-(3,4,5-trimethoxy-phenyl)-ethyl]-2-methoxy-phenol
SR-01000946784-1
COMBRETASTATIN A-4 [MI]
Phenol, 2-methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]-
combretastin A4
s7783
NSC-817373

MDL Number

MFCD03453309

Customs Code

29095000

FAQ

What is Combretastatin A4 (CAS: 117048-59-6)?

Combretastatin A4 is a natural compound derived from the African shrub *Combretum caffrum*. It has the chemical formula C21H22O9 and is known for its potential anti-cancer properties. This compound belongs to the class of flavonoids and exhibits cytotoxic activity against various cancer cell lines. Combretastatin A4 is also used in research for its ability to inhibit microtubule assembly, making it a valuable tool in drug discovery and development.

What are the main uses of Combretastatin A4 (CAS: 117048-59-6)?

Combretastatin A4 is primarily used in pharmaceutical research for its anti-tumor properties. It has been studied as a potential chemotherapeutic agent due to its ability to disrupt blood vessel formation in tumors. Additionally, it is used in biochemical studies to investigate microtubule dynamics and in the development of targeted cancer therapies. The compound's unique structure also makes it relevant in the study of plant-derived medicines and natural products.

Is Combretastatin A4 (CAS: 117048-59-6) safe?

Combretastatin A4 is generally considered safe when handled properly in laboratory settings. However, like many potent compounds, it requires careful handling to avoid skin contact or inhalation. Safety data suggests that it has low acute toxicity, but long-term effects are still under investigation. Always follow standard safety protocols, including the use of gloves and a fume hood, when working with Combretastatin A4 to ensure proper protection.

How should Combretastatin A4 (CAS: 117048-59-6) be stored?

Combretastatin A4 should be stored in a cool, dry, and dark place, ideally at 4°C. It is recommended to keep it in a sealed container to prevent moisture and contamination. Avoid exposure to light and air to maintain its stability and potency. Proper storage conditions are essential to ensure the compound remains effective for research and potential therapeutic applications.