Combretastatin A4(CAS: 117048-59-6)

Combretastatin A4 is a natural compound derived from the African shrub *Combretum caffrum*. It has the chemical formula C21H22O9 and is known for its potential anti-cancer properties. This compound belongs to the class of flavonoids and exhibits cytotoxic activity against various cancer cell lines. Combretastatin A4 is also used in research for its ability to inhibit microtubule assembly, making it a valuable tool in drug discovery and development.

Combretastatin A4 is primarily used in pharmaceutical research for its anti-tumor properties. It has been studied as a potential chemotherapeutic agent due to its ability to disrupt blood vessel formation in tumors. Additionally, it is used in biochemical studies to investigate microtubule dynamics and in the development of targeted cancer therapies. The compound's unique structure also makes it relevant in the study of plant-derived medicines and natural products.

Combretastatin A4 is generally considered safe when handled properly in laboratory settings. However, like many potent compounds, it requires careful handling to avoid skin contact or inhalation. Safety data suggests that it has low acute toxicity, but long-term effects are still under investigation. Always follow standard safety protocols, including the use of gloves and a fume hood, when working with Combretastatin A4 to ensure proper protection.

Combretastatin A4 should be stored in a cool, dry, and dark place, ideally at 4°C. It is recommended to keep it in a sealed container to prevent moisture and contamination. Avoid exposure to light and air to maintain its stability and potency. Proper storage conditions are essential to ensure the compound remains effective for research and potential therapeutic applications.