5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine | CAS No. 1131770-46-1
5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine
Basic Information
CAS Number
1131770-46-1
Molecular Formula
C16H10ClFINS
Molecular Weight
429.69 g/mol
AD
Chemical Classification
Basic Physical Properties
Synonyms & References
English
- 5-(5-(2-Chloro-5-iodobenzyl)thiophen-2-yl)-2-fluoropyridine
- 5-[5-[(2-Chloro-5-iodophenyl)methyl]-2-thienyl]-2-fluoropyridine
- 2-(2-Chloro-5-iodinebenzyl)-5-(3-(6-fluoropyridyl))thiophene
- 5-[5-[(2-chloro-5-iodophenyl)methyl]thiophen-2-yl]-2-fluoropyridine
MDL Number
MFCD12405595
FAQ
What are the physical and chemical properties of 5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine (CAS: 1131770-46-1)?
5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine has a crystalline form with a molecular weight of approximately 512.85 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and dimethylformamide. This compound is known for its high reactivity, particularly in nucleophilic substitution reactions.
How is 5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine (CAS: 1131770-46-1) typically synthesized?
5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine is synthesized via a multistep process involving the coupling of 2-fluoropyridine with 2-chloro-5-iodobenzyl thioether, followed by the introduction of the thiophene ring. Commonly used catalysts include palladium(II) acetate in the presence of a ligand. The overall yield is typically around 60-70%.
What industries use 5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine (CAS: 1131770-46-1)?
This compound finds applications in pharmaceuticals, primarily as an intermediate in the synthesis of more complex drugs. It is also used in the development of sensors and as a potential material for semiconductors due to its unique electronic properties.
What precautions should be taken when handling 5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine (CAS: 1131770-46-1)?
When handling 5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine, use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store in a cool, dry place away from direct sunlight. In case of a spill, use a spill kit, and consult the Safety Data Sheet (SDS) for specific guidelines. This compound requires fume hood use during synthesis due to its volatility and potential for generating toxic gases.
Related Compounds
![N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure](https://static.chemtradehub.com/structs/103/103687-96-3-8086.webp "N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine structure")
N-(2-Methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-beta-alanine
CAS Number:
103687-96-3
Molecular Formula:
C17H19NO5S
![5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure](https://static.chemtradehub.com/structs/112/112897-99-1-d1f4.webp "5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine structure")
5'-O-[Bis(4-methoxyphenyl)(phenyl)methyl]cytidine
CAS Number:
112897-99-1
Molecular Formula:
C30H31N3O7
![(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure](https://static.chemtradehub.com/structs/121/121055-10-5-583d.webp "(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile structure")
(3S,4R)-3-Hydroxy-2,2-dimethyl-4-[(3-oxo-1-cyclopenten-1-yl)oxy]-6-chromanecarbonitrile
CAS Number:
121055-10-5
Molecular Formula:
C17H17NO4
![Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure](https://static.chemtradehub.com/structs/126/1263059-26-2-d6da.webp "Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate structure")
Methyl 5-chloropyrazolo[1,5-a]pyrimidine-2-carboxylate
CAS Number:
1263059-26-2
Molecular Formula:
C8H6ClN3O2
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