5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine(CAS: 1131770-46-1)

5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine has a crystalline form with a molecular weight of approximately 512.85 g/mol. It is poorly soluble in water but soluble in organic solvents such as ethanol and dimethylformamide. This compound is known for its high reactivity, particularly in nucleophilic substitution reactions.

5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine is synthesized via a multistep process involving the coupling of 2-fluoropyridine with 2-chloro-5-iodobenzyl thioether, followed by the introduction of the thiophene ring. Commonly used catalysts include palladium(II) acetate in the presence of a ligand. The overall yield is typically around 60-70%.

This compound finds applications in pharmaceuticals, primarily as an intermediate in the synthesis of more complex drugs. It is also used in the development of sensors and as a potential material for semiconductors due to its unique electronic properties.

When handling 5-[5-(2-Chloro-5-iodobenzyl)-2-thienyl]-2-fluoropyridine, use personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Store in a cool, dry place away from direct sunlight. In case of a spill, use a spill kit, and consult the Safety Data Sheet (SDS) for specific guidelines. This compound requires fume hood use during synthesis due to its volatility and potential for generating toxic gases.