(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid

Basic Information

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CAS Number

1088496-42-7

Molecular Formula

C8H12BNO3

Molecular Weight

181 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Basic Physical Properties

SMILES

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B(C1=CN=C(C=C1)C(C)(C)O)(O)O

InChI

InChI=1S/C8H12BNO3/c1-6(5-11)8-3-2-7(4-10-8)9(12)13/h2-4,6,11-13H,5H2,1H3

InChIKey

UGEQHBKYUPTOPV-UHFFFAOYSA-N

LogP

-1.1428

Topological Polar Surface Area

73.58000000000001 Å²

Hydrogen Bond Donor/Acceptor

3 / 4

Complexity

175

Synonyms & References

English

(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid
6-(2-hydroxypropan-2-yl)pyridin-3-ylboronic acid
6-(2-HYDROXYPROPAN-2-YL)PYRIDINE-3-BORONIC ACID
D-5233
A895179
1088496-42-7
HQNCOBIVRYULKH-UHFFFAOYSA-N
DTXSID10717197
6-(2-Hydroxy-2-propyl)pyridine-3-boronic Acid
AT35759
[6-(2-Hydroxypropan-2-yl)pyridin-3-yl]boronic acid
AMY19088
MFCD09992916
SY345591
6-(2-Hydroxypropan-2-yl)pyridin-3-ylboronic acid
TQP1168
CS-0140557
AKOS006313840
[6-(1-hydroxy-1-methylethyl)pyridin-3-yl]boronic acid
SCHEMBL2556277

MDL Number

MFCD09992916

Customs Code

2933399090

FAQ

What are the physical and chemical properties of (6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid (CAS: 1088496-42-7)?

(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid is a crystalline solid with a molecular weight of approximately 279.25 g/mol. It has a solubility of about 0.001 g/100 mL in water. This compound is known for its reactivity in boron-containing reactions and its ability to act as a boronic acid derivative, which is common in Suzuki coupling reactions. It is also stable under normal laboratory conditions but may react with strong acids or bases.

How is (6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid (CAS: 1088496-42-7) typically synthesized?

(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid can be synthesized using a multi-step process starting from 2-hydroxypropyl pyridine and boronic acid. The synthesis involves protecting the hydroxyl group, followed by a reaction with boronic acid in the presence of a palladium catalyst and a base. The yield is typically around 70-80%, with high selectivity for the desired product.

What industries use (6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid (CAS: 1088496-42-7)?

(6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of various drugs and also finds applications in the development of functional polymers. Additionally, it is used in the field of sensors for its unique boronic acid functionality.

What precautions should be taken when handling (6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid (CAS: 1088496-42-7)?

When handling (6-(2-Hydroxypropan-2-yl)pyridin-3-yl)boronic acid, it is important to wear appropriate personal protective equipment (PPE), including gloves and goggles. It should be stored in a cool, dry place, away from strong acids and bases. In case of a spill, it should be cleaned up immediately using appropriate absorbent materials. Always refer to the Material Safety Data Sheet (MSDS) for detailed safety information.