2-(2-Thienyl)phenol

Basic Information

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CAS Number

106584-13-8

Molecular Formula

C10H8OS

Molecular Weight

176.24 g/mol

Basic Physical Properties

Boiling Point

291.5°C at 760 mmHg

Density

1.235

Flash Point

130.1°C

Refractive Index

1.635

SMILES

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C1=CC=C(C(=C1)C2=CC=CS2)O

InChI

InChI=1S/C10H8OS/c11-9-5-2-1-4-8(9)10-6-3-7-12-10/h1-7,11H

InChIKey

IGXFRPBULGVNKY-UHFFFAOYSA-N

LogP

3.120700000000001

Topological Polar Surface Area

20.23 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

149

Synonyms & References

English

A15092
AKOS004114057
W17135
AMY39709
SCHEMBL1062980
2-(thiophen-2-yl)phenol
2-(2-Thienyl)-phenol
106584-13-8
DTXSID90393695
BB 0222687
2 (2-THIENYL) PHENOL
AS-57998
FT-0768433
MFCD06801791
2-thiophen-2-ylphenol
2-(2-THIENYL)PHENOL
CS-0060471
2-(Thiophen-2-yl)phenol
2-(2-hydroxyphenyl)thiophene
2-(2'-hydroxyphenyl)thiophene

MDL Number

MFCD06801791

Customs Code

2934999090

FAQ

What are the physical and chemical properties of 2-(2-Thienyl)phenol (CAS: 106584-13-8)?

2-(2-Thienyl)phenol (CAS: 106584-13-8) is a crystalline solid with a molecular weight of approximately 182.18 g/mol. It has a low melting point of about 73-74°C. The compound is slightly soluble in water but soluble in common organic solvents such as ethanol and acetone. It is chemically stable but can react with strong oxidizing agents and light exposure. This compound is often used in organic synthesis due to its reactivity.

How is 2-(2-Thienyl)phenol (CAS: 106584-13-8) typically synthesized?

2-(2-Thienyl)phenol is typically synthesized via the phenol-thiophene coupling reaction. A common method involves the reaction of 2-chloro-2-thiophenethiol with phenol in the presence of a base like sodium hydroxide. The reaction is carried out in an aprotic polar solvent, yielding a product with excellent selectivity and moderate yield. This method is widely used in academic and industrial settings.

What industries use 2-(2-Thienyl)phenol (CAS: 106584-13-8)?

2-(2-Thienyl)phenol (CAS: 106584-13-8) is primarily used in the pharmaceutical and polymer industries. It serves as a key intermediate in the synthesis of medicinal compounds and is also utilized in the production of functional polymers. Additionally, due to its chemical properties, it finds applications in sensor technology and semiconductor manufacturing.

What precautions should be taken when handling 2-(2-Thienyl)phenol (CAS: 106584-13-8)?

When handling 2-(2-Thienyl)phenol (CAS: 106584-13-8), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of a spill, use appropriate containment and clean up with care, as the compound can react with oxidizing agents. Always refer to the Safety Data Sheet (SDS) for detailed handling instructions.