4-(3-Fluorophenyl)piperidine hydrochloride (1:1)

Basic Information

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CAS Number

104774-94-9

Molecular Formula

C11H15ClFN

Molecular Weight

215.7 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Basic Physical Properties

Physical State

White to Yellow Solid

Boiling Point

292.1°Cat760mmHg

Flash Point

130.4°C

SMILES

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C1CNCCC1C2=CC(=CC=C2)F.Cl

InChI

InChI=1S/C11H14FN.ClH/c12-11-3-1-2-10(8-11)9-4-6-13-7-5-9;/h1-3,8-9,13H,4-7H2;1H

InChIKey

KZWKZINPPPZZCE-UHFFFAOYSA-N

LogP

2.7145

Topological Polar Surface Area

12.03 Å²

Hydrogen Bond Donor/Acceptor

1 / 1

Complexity

154

Safety Information

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GHS Hazard Pictograms

H412

Hazard Statement

H412 Harmful to aquatic life with long lasting effects
Hazardous to the aquatic environment, long-term hazard

Hazard Class

Class IRRITANT Class IRRITANT

Synonyms & References

English

AB10960
A13346
Piperidine, 4-(3-fluorophenyl)-, hydrochloride
SCHEMBL1765281
4-(3-Fluorophenyl)piperidine HCl
4-(3-Fluorophenyl)-piperidine, HCl
4-(3-fluoro-phenyl)-piperidine hydrochloride
4-(3-fluorophenyl)piperidine hydrochloride
4-(3-Fluorophenyl)-piperidinehydrochloride
CS-0060404
AS-37421
DTXSID20660822
AKOS015849151
FT-0658831
EN300-77720
Q-102984
104774-94-9
4-(3-fluorophenyl) piperidine hydrochloride
4-(3-FLUOROPHENYL)-PIPERIDINE HCL
4-(3-Fluorophenyl)piperidine;hydrochloride
4-(3-fluorophenyl)piperidinehydrochloride
4-(3-Fluorophenyl)-piperidine hydrochloride
4-(3-Fluorophenyl)piperidine--hydrogen chloride (1/1)
Z1342208423
4-(3-fluorophenyl)-piperidine hydrochloride, AldrichCPR
MFCD02178901
4-(3-Fluorophenyl)piperidine hydrochloride
4-(3-FLUOROPHENYL)-PIPERIDINE HYDROCHLORIDE
Piperidine,4-(3-fluorophenyl)-, hydrochloride (1:1)
4-(3-Fluorophenyl)-piperidine hy
4-(3-FLUOROPHENYL)-PIPERIDINE HYDROCHLORIDE（WS203863）

MDL Number

MFCD02178901

Customs Code

2933399090

FAQ

What are the physical and chemical properties of 4-(3-Fluorophenyl)piperidine hydrochloride (CAS: 104774-94-9)?

4-(3-Fluorophenyl)piperidine hydrochloride is a white crystalline solid with a molecular weight of 260.71 g/mol. It has a pKa of approximately 1.3 and is highly soluble in water and less soluble in organic solvents like methanol and ethyl acetate. It is moderately reactive with bases and can undergo hydrolysis under basic conditions. It is often used in pharmaceutical applications due to its stability and solubility properties.

How is 4-(3-Fluorophenyl)piperidine hydrochloride (CAS: 104774-94-9) typically synthesized?

4-(3-Fluorophenyl)piperidine hydrochloride is typically synthesized via a multi-step process involving the coupling of 3-fluorophenyl chloride and piperidine, followed by protonation to form the hydrochloride salt. Commonly used catalysts include triethylamine and diisopropylethylamine. The yield is generally around 70-80%, and the reaction is carried out under mild conditions to ensure high selectivity.

What industries use 4-(3-Fluorophenyl)piperidine hydrochloride (CAS: 104774-94-9)?

4-(3-Fluorophenyl)piperidine hydrochloride is primarily used in the pharmaceutical industry for the development of new drugs. It is also used in the polymer industry as a monomer or additive. Additionally, it has applications in the production of sensors and semiconductors due to its unique chemical properties.

What precautions should be taken when handling 4-(3-Fluorophenyl)piperidine hydrochloride (CAS: 104774-94-9)?

When handling 4-(3-Fluorophenyl)piperidine hydrochloride, it is crucial to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. The substance should be handled in a well-ventilated area or fume hood to prevent inhalation. In case of a spill, it should be immediately cleaned up using appropriate spill kits. The safety data sheet (SDS) should be consulted for detailed information on handling and storage procedures.