4-(3-Fluorophenyl)piperidine hydrochloride (1:1)(CAS: 104774-94-9)

4-(3-Fluorophenyl)piperidine hydrochloride is a white crystalline solid with a molecular weight of 260.71 g/mol. It has a pKa of approximately 1.3 and is highly soluble in water and less soluble in organic solvents like methanol and ethyl acetate. It is moderately reactive with bases and can undergo hydrolysis under basic conditions. It is often used in pharmaceutical applications due to its stability and solubility properties.

4-(3-Fluorophenyl)piperidine hydrochloride is typically synthesized via a multi-step process involving the coupling of 3-fluorophenyl chloride and piperidine, followed by protonation to form the hydrochloride salt. Commonly used catalysts include triethylamine and diisopropylethylamine. The yield is generally around 70-80%, and the reaction is carried out under mild conditions to ensure high selectivity.

4-(3-Fluorophenyl)piperidine hydrochloride is primarily used in the pharmaceutical industry for the development of new drugs. It is also used in the polymer industry as a monomer or additive. Additionally, it has applications in the production of sensors and semiconductors due to its unique chemical properties.

When handling 4-(3-Fluorophenyl)piperidine hydrochloride, it is crucial to wear appropriate personal protective equipment (PPE) including gloves and safety goggles. The substance should be handled in a well-ventilated area or fume hood to prevent inhalation. In case of a spill, it should be immediately cleaned up using appropriate spill kits. The safety data sheet (SDS) should be consulted for detailed information on handling and storage procedures.