Biotin-PEG2-C4-alkyne

Basic Information

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CAS Number

1011268-28-2

Molecular Formula

C22H36N4O5S

Molecular Weight

16.04 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Polymers and Plastics Thermoplastics Polyolefins

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Boiling Point

799.8±60.0 °C(Predicted)

Density

1.158±0.06 g/cm3(Predicted)

Solubility

Soluble in DMSO, DMF

SMILES

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C#CCCCC(=O)NCCOCCOCCNC(=O)CCCC[C@@H]1SC[C@H]2[C@@H]1NC(=O)N2

InChI

InChI=1S/CH4/h1H4

InChIKey

VNWKTOKETHGBQD-UHFFFAOYSA-N

LogP

0.6361

pKa

13.90±0.40(Predicted)

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

654

Synonyms & References

English

Biotin-PEG2-C4-Alkyne
1H-Thieno[3,4-d]imidazole-4-pentanamide, hexahydro-2-oxo-N-[2-[2-[2-[(1-oxo-5-hexyn-1-yl)amino]ethoxy]ethoxy]ethyl]-, (3aS,4S,6aR)-
Biotin-PEG2-C4-alkyne

MDL Number

MFCD28505539

FAQ

What are the physical and chemical properties of Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2)?

Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2) is a biotinylated polyethylene glycol derivative with a C4 alkynyl group. It is typically a white to off-white powder with a molecular weight around 615 g/mol. This compound is poorly soluble in water but soluble in organic solvents such as DMSO and CHCl3. It is reactive due to the presence of the alkynyl group, which can undergo copper-catalyzed azide-alkyne click chemistry, making it useful for conjugation reactions.

How is Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2) typically synthesized?

Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2) is synthesized by linking a biotin moiety to a polyethylene glycol (PEG) chain through a C4 alkynyl group. Commonly, biotin is attached to the PEG chain via an amide bond. The synthesis typically involves coupling biotin hydrazide with the carboxylic acid of the C4 alkynyl-PEG2 derivative. This process can be optimized using specific coupling agents and conditions to achieve high yields and selectivity.

What industries use Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2)?

Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2) is widely used in the pharmaceutical, biotechnology, and diagnostics industries. It is particularly valuable for conjugating biomolecules to surfaces or other molecules for biosensor applications, drug delivery systems, and affinity chromatography. Additionally, it is used in polymer science for functionalizing polymers and in semiconductor industry for surface modification and patterning.

What precautions should be taken when handling Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2)?

When handling Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to the vapors. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.