Biotin-PEG2-C4-alkyne(CAS: 1011268-28-2)

Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2) is a biotinylated polyethylene glycol derivative with a C4 alkynyl group. It is typically a white to off-white powder with a molecular weight around 615 g/mol. This compound is poorly soluble in water but soluble in organic solvents such as DMSO and CHCl3. It is reactive due to the presence of the alkynyl group, which can undergo copper-catalyzed azide-alkyne click chemistry, making it useful for conjugation reactions.

Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2) is synthesized by linking a biotin moiety to a polyethylene glycol (PEG) chain through a C4 alkynyl group. Commonly, biotin is attached to the PEG chain via an amide bond. The synthesis typically involves coupling biotin hydrazide with the carboxylic acid of the C4 alkynyl-PEG2 derivative. This process can be optimized using specific coupling agents and conditions to achieve high yields and selectivity.

Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2) is widely used in the pharmaceutical, biotechnology, and diagnostics industries. It is particularly valuable for conjugating biomolecules to surfaces or other molecules for biosensor applications, drug delivery systems, and affinity chromatography. Additionally, it is used in polymer science for functionalizing polymers and in semiconductor industry for surface modification and patterning.

When handling Biotin-PEG2-C4-alkyne (CAS: 1011268-28-2), it is crucial to use appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize exposure to the vapors. Spills should be cleaned up using appropriate absorbent materials, and the area should be thoroughly rinsed with water. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.