5-Nitro-2-(trifluoromethyl)pyridine(CAS: 116470-66-7)

5-Nitro-2-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 238.06 g/mol. It has limited water solubility and is moderately soluble in organic solvents like methanol and acetonitrile. Chemically, it is reactive, especially towards nucleophiles and reducing agents, and it can undergo nitration and reduction reactions.

5-Nitro-2-(trifluoromethyl)pyridine is typically synthesized via the nitration of 2-(trifluoromethyl)pyridine using a mixture of nitric acid and sulfuric acid as the oxidizing agent. The reaction is carried out under reflux to achieve high yield and selectivity.

5-Nitro-2-(trifluoromethyl)pyridine finds applications in the pharmaceutical industry for the synthesis of certain drugs, in the semiconductor industry for use in photoresists, and in the polymer industry for the development of advanced materials.

When handling 5-Nitro-2-(trifluoromethyl)pyridine, always wear appropriate personal protective equipment (PPE) including gloves and goggles. Work in a well-ventilated area or fume hood due to its volatility and potential for inhalation hazards. Spills should be cleaned up immediately with appropriate absorbents and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety information.