1-Chloro-3-fluoro-5-nitrobenzene(CAS: 4815-64-9)

1-Chloro-3-fluoro-5-nitrobenzene (CAS: 4815-64-9) is a crystalline solid with a molecular weight of 211.58 g/mol. It has a low solubility in water but is more soluble in organic solvents like acetone and dichloromethane. Chemically, it is highly reactive with reducing agents and aromatic amines, making it useful in various synthetic reactions.

1-Chloro-3-fluoro-5-nitrobenzene (CAS: 4815-64-9) can be synthesized through the nitration of 1-chloro-3-fluorobenzene. This process typically involves the use of a mixture of nitric acid and sulfuric acid as the nitrating agent. The yield is approximately 85%, and the selectivity towards the 5-nitro position is very high.

1-Chloro-3-fluoro-5-nitrobenzene (CAS: 4815-64-9) is primarily used in the pharmaceutical and chemical industries for the synthesis of intermediates and active pharmaceutical ingredients. It also finds applications in the production of dyes and other organic compounds.

When handling 1-Chloro-3-fluoro-5-nitrobenzene (CAS: 4815-64-9), it is essential to wear appropriate personal protective equipment (PPE) such as gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood. Spills should be cleaned up immediately using appropriate absorbents, and the material safety data sheet (MSDS) should be consulted for detailed safety information.