5-Nitro-2-(trifluoromethyl)pyridine

Basic Information

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CAS Number

116470-66-7

Molecular Formula

C6H3F3N2O2

Molecular Weight

192.1 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Electronic Chemicals Semiconductor Materials Etchants

Basic Physical Properties

Boiling Point

217 ºC

Flash Point

85 ºC

SMILES

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C1=CC(=NC=C1[N+](=O)[O-])C(F)(F)F

InChI

InChI=1S/C6H3F3N2O2/c7-6(8,9)5-2-1-4(3-10-5)11(12)13/h1-3H

InChIKey

ZTSJYRKGWJZNON-UHFFFAOYSA-N

LogP

2.53180

Complexity

201

Safety Information

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Hazard Class

Class IRRITANT-HARMFUL Class IRRITANT-HARMFUL

Synonyms & References

English

E77873
5-nitro-2-(trifluoromethyl)pyridine
AKOS005259583
5-Nitro-2-trifluoromethylpyridine
MFCD07777204
BS-51509
116470-66-7
Pyridine, 5-nitro-2-(trifluoromethyl)-
5-NITRO-2-(TRIFLUOROMETHYL)PYRIDINE, 98%
CS-0029855
2-(Trifluoromethyl)-5-nitropyridine
ZTSJYRKGWJZNON-UHFFFAOYSA-N
FT-0683860
Pyridine,5-nitro-2-(trifluoromethyl)-
DTXSID50554189
A803621
5-Nitro-2-(trifluoromethyl)pyridine

MDL Number

MFCD07777204

FAQ

What are the physical and chemical properties of 5-Nitro-2-(trifluoromethyl)pyridine (CAS: 116470-66-7)?

5-Nitro-2-(trifluoromethyl)pyridine is a crystalline solid with a molecular weight of approximately 238.06 g/mol. It has limited water solubility and is moderately soluble in organic solvents like methanol and acetonitrile. Chemically, it is reactive, especially towards nucleophiles and reducing agents, and it can undergo nitration and reduction reactions.

How is 5-Nitro-2-(trifluoromethyl)pyridine (CAS: 116470-66-7) typically synthesized?

5-Nitro-2-(trifluoromethyl)pyridine is typically synthesized via the nitration of 2-(trifluoromethyl)pyridine using a mixture of nitric acid and sulfuric acid as the oxidizing agent. The reaction is carried out under reflux to achieve high yield and selectivity.

What industries use 5-Nitro-2-(trifluoromethyl)pyridine (CAS: 116470-66-7)?

5-Nitro-2-(trifluoromethyl)pyridine finds applications in the pharmaceutical industry for the synthesis of certain drugs, in the semiconductor industry for use in photoresists, and in the polymer industry for the development of advanced materials.

What precautions should be taken when handling 5-Nitro-2-(trifluoromethyl)pyridine (CAS: 116470-66-7)?

When handling 5-Nitro-2-(trifluoromethyl)pyridine, always wear appropriate personal protective equipment (PPE) including gloves and goggles. Work in a well-ventilated area or fume hood due to its volatility and potential for inhalation hazards. Spills should be cleaned up immediately with appropriate absorbents and disposed of according to local regulations. Refer to the Safety Data Sheet (SDS) for detailed safety information.