Aureobasidin A(CAS: 127785-64-2)

Aureobasidin A (CAS: 127785-64-2) is a cyclic depsipeptide with a molecular weight of approximately 506.4 g/mol. It is sparingly soluble in water but highly soluble in organic solvents like methanol and acetonitrile. Chemically, it exhibits moderate reactivity towards nucleophiles and is stable under acidic and neutral conditions but can be degraded under basic conditions. Its crystalline form has been characterized by X-ray crystallography, revealing a unique cyclic structure with specific hydrogen bonding patterns.

Aureobasidin A (CAS: 127785-64-2) is typically synthesized through a multi-step chemical process involving peptide coupling, amidation, and cyclization reactions. The key synthetic route involves the condensation of suitable amino acids, followed by peptide bond formation and cyclization. The use of catalysts such as HOBt and DCC is common to enhance reactivity and selectivity. The overall yield is around 40-50%, and the method is known for its high chemical and enantioselectivity.

Aureobasidin A (CAS: 127785-64-2) finds applications in various industries. In pharmaceuticals, it has potential as an antifungal agent. It is also used in polymer synthesis as a molecular weight regulator, in sensor technology for detection of specific biomarkers, and in semiconductor manufacturing for quality control. Its bioactive properties make it valuable in both research and commercial applications.

When handling Aureobasidin A (CAS: 127785-64-2), it is essential to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. Work should be conducted in a well-ventilated area or a fume hood to minimize inhalation risks. In case of skin contact, immediately wash the affected area with soap and water. If swallowed, do not induce vomiting and seek medical attention. Keep the compound away from sources of heat and ensure proper storage in a cool, dry place. Always consult the Material Safety Data Sheet (MSDS) for detailed safety information and emergency procedures.