Ticagrelor | CAS No. 274693-27-5

Ticagrelor

Basic Information

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CAS Number

274693-27-5

Molecular Formula

C23H28F2N6O4S

Molecular Weight

522.58 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Ethers

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Surfactants Anionic Surfactants

Fine Chemicals Specialty Chemicals UV Stabilizers

Agricultural Chemicals Pesticides Herbicides

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Melting Point

149-154 °C

Boiling Point

777.551°C at 760 mmHg

Refractive Index

1.74

SMILES

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CCCSC1=NC(=C2C(=N1)N(N=N2)C3CC(C(C3O)O)OCCO)NC4CC4C5=CC(=C(C=C5)F)F

InChI

InChI=1S/C23H28F2N6O4S/c1-2-7-36-23-27-21(26-15-9-12(15)11-3-4-13(24)14(25)8-11)18-22(28-23)31(30-29-18)16-10-17(35-6-5-32)20(34)19(16)33/h3-4,8,12,15-17,19-20,32-34H,2,5-7,9-10H2,1H3,(H,26,27,28)/t12-,15+,16+,17-,19-,20+/m0/s1

InChIKey

OEKWJQXRCDYSHL-FNOIDJSQSA-N

LogP

2.0136999999999996

Topological Polar Surface Area

138.44 Å²

Hydrogen Bond Donor/Acceptor

4 / 10

Complexity

736

Safety Information

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Hazard Statement

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

TICAGRELOR [ORANGE BOOK]
HMS3885B03
Possia
(1S,2S,3R,5S)-3-(7-((1R,2S)-2-(3,4-Difluorophenyl)cyclopropylamino)-5-(propylthio)-3H-(1,2,3)triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
CHEBI:68558
Ticagrelor [USAN:INN:BAN]
SCHEMBL1979652
Ticagrelor (JAN/USAN/INN)
AB01565855_02
1,2-Cyclopentanediol, 3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-1,2,3-triazolo(4,5-d)pyrimidin-3-yl)-5-(2-hydroxyethoxy)-, (1S,2S,3R,5S)-
TICAGRELOR [WHO-DD]
UNII-GLH0314RVC
TICARGRELOR
(1S,2S,3R,5S)-3-[7-[[(1R,2S)-2-(3,4-D1,2-Cyclopentanediolifluorophenyl)cyclopropyl]amino]-5-(propylthio)-3H-1,2,3-triazolo[4,5-d]pyrimidin-3-yl]-5-(2-hydroxyethoxy)-1,2-cyclopentanediol
AR-C126532
compound 17 (PMID: 17827008)
AZD6140
TICAGRELOR (USP-RS)
AM85693
Brilinta
274693-27-5
TICAGRELOR [JAN]
CHEMBL398435
AZD-6140
A850981
(1S,2S,3R,5S)-3-(7-(((1R,2S)-2-(3,4-difluorophenyl)cyclopropyl)amino)-5-(propylthio)-3H-[1,2,3]triazolo[4,5-d]pyrimidin-3-yl)-5-(2-hydroxyethoxy)cyclopentane-1,2-diol
EX-A503
AR-C 126532XX
[14C]-Ticagrelor
Brilique
TICAGRELOR [MI]

MDL Number

MFCD09954148

Customs Code

2933990090

FAQ

What is Ticagrelor (CAS: 274693-27-5)?

Ticagrelor is an antiplatelet medication used to prevent blood clots. Its chemical formula is C19H18N4O4S2, and it is a white to off-white crystalline powder. It is highly soluble in DMSO and has a molecular weight of 414.48 g/mol. Ticagrelor works by inhibiting the P2Y12 receptor on platelets, thereby reducing the risk of cardiovascular events.

What are the main uses of Ticagrelor (CAS: 274693-27-5)?

Ticagrelor is primarily used in the treatment of patients with acute coronary syndrome (ACS) to reduce the risk of heart attack, stroke, and death. It is also prescribed for long-term prevention of atherothrombotic events in individuals who have had a recent myocardial infarction. As a P2Y12 receptor antagonist, it plays a key role in antiplatelet therapy and is widely used in pharmaceutical research.

Is Ticagrelor (CAS: 274693-27-5) safe?

Ticagrelor is generally considered safe when used as directed. It is approved by regulatory authorities like the FDA and EMA for its therapeutic use. However, like all medications, it may cause side effects such as bleeding, dyspnea, or bruising. Proper handling and adherence to safety guidelines are essential to minimize risks and ensure safe administration.

How should Ticagrelor (CAS: 274693-27-5) be stored?

Ticagrelor should be stored in a cool, dry place away from moisture and light. It is typically kept at a temperature between 15°C to 30°C (59°F to 86°F) in a sealed container. Avoid exposure to high humidity and direct sunlight to maintain its stability and efficacy over time.