Linagliptin | CAS No. 668270-12-0

Linagliptin

Basic Information

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CAS Number

668270-12-0

Molecular Formula

C25H28N8O2

Molecular Weight

30.07 g/mol

Chemical Classification

Basic Chemical Raw Materials Organic Chemicals Carboxylic Acids

Basic Chemical Raw Materials Organic Chemicals Amines

Basic Chemical Raw Materials Organic Chemicals Nitriles

Basic Chemical Raw Materials Organic Chemicals Heterocyclic Compounds

Pharmaceutical Chemicals Pharmaceutical Intermediates Heterocyclic Intermediates

Fine Chemicals Dyes and Pigments Organic Dyes

Fine Chemicals Surfactants Anionic Surfactants

Laboratory Chemicals Research Chemicals Biochemical Reagents

Basic Physical Properties

Physical State

Powder

Melting Point

202ºC

Boiling Point

661.2°C at 760 mmHg

Density

1.39

SMILES

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CC#CCN1C2=C(N=C1N3CCCC(C3)N)N(C(=O)N(C2=O)CC4=NC5=CC=CC=C5C(=N4)C)C

InChI

InChI=1S/C2H6/c1-2/h1-2H3

InChIKey

OTMSDBZUPAUEDD-UHFFFAOYSA-N

LogP

1.0262

Topological Polar Surface Area

0.0 Å²

Hydrogen Bond Donor/Acceptor

0 / 0

Complexity

885

Safety Information

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Hazard Statement

H302 Harmful if swallowed
Acute toxicity, oral

H315 Causes skin irritation
Skin corrosion/irritation

H319 Causes serious eye irritation
Serious eye damage/eye irritation

H332 Harmful if inhaled
Acute toxicity, inhalation

H335 May cause respiratory irritation
Specific target organ toxicity, single exposure; Respiratory tract irritation

Synonyms & References

English

(R)-8-(3-aminopiperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methylquinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
BS 1356 BS
Tradjenta (TN)
(R)-8-(3-Amino-piperidin-1-yl)-7-but-2-ynyl-3-methyl-1-(4-methyl-quinazolin-2-ylmethyl)-3,7-dihydro-purine-2,6-dione
LINAGLIPTIN [ORANGE BOOK]
(R)-8-(3-aminopiperidin-1-yl)-7-(but-2-yn-1-yl)-3-methyl-1-((4-methylquinazolin-2-yl)methyl)-3,7-dihydro-1H-purine-2,6-dione
CHEMBL237500
BI-1356BS
BDBM50228403
DTXSID201021653
Z2235801970
Trajenta
GTPL6318
LINAGLIPTIN (MART.)
BCP02462
Linaglitpin
1H-Purine-2,6-dione, 8-((3R)-3-amino-1-piperidinyl)-7-(2-butynyl)-3,7-dihydro-3-methyl-1-((4-methyl-2-quinazolinyl)methyl)-
AB01563307_03
Linagliptina
BI-1356
DB08882
LINAGLIPTIN [USAN]
LTXREWYXXSTFRX-QGZVFWFLSA-N
NS00098773
Linagliptin
linagliptinum
1-[(4-methyl-quinazolin-2-yl)methyl]-3-methyl-7-(2-butyn-1-yl)-8-(3-(R)aminopiperidin-1-yl)xanthine
AKOS015995251
NCGC00346655-02
ione
LINAGLIPTIN [VANDF]

MDL Number

MFCD14635356

FAQ

What is [compound name] (CAS: 668270-12-0)?

Linagliptin is a pharmaceutical compound with the CAS number 668270-12-0. It is a dipeptidyl peptidase-4 (DPP-4) inhibitor used primarily in the treatment of type 2 diabetes. Its chemical formula is C16H21N3O3S, and it is a white to off-white solid at room temperature with good solubility in dimethyl sulfoxide (DMSO).

What are the main uses of [compound name] (CAS: 668270-12-0)?

Linagliptin is mainly used as a medication to manage blood sugar levels in patients with type 2 diabetes. It works by inhibiting the enzyme DPP-4, which helps increase the levels of incretin hormones that stimulate insulin production. It is also used in research for studying metabolic disorders and as an active pharmaceutical ingredient in drug formulations.

Is [compound name] (CAS: 668270-12-0) safe?

Linagliptin is generally considered safe when used as directed under medical supervision. It has a favorable safety profile with minimal side effects, though precautions should be taken in patients with severe kidney disease. Safety standards are in place to ensure proper handling and administration in pharmaceutical settings.

How should [compound name] (CAS: 668270-12-0) be stored?

Linagliptin should be stored in a cool, dry place away from moisture and light. It is typically kept at room temperature (15-30°C) and protected from humidity. Proper storage ensures its stability and efficacy over time, as specified by pharmaceutical guidelines.