Ethyl 5-amino-1-benzofuran-2-carboxylate(CAS: 174775-48-5)

Ethyl 5-amino-1-benzofuran-2-carboxylate (CAS: 174775-48-5) is a crystalline solid with a molecular weight of approximately 231.26 g/mol. It is slightly soluble in water and more soluble in organic solvents. This compound exhibits moderate reactivity with basic and acidic compounds, making it useful in various chemical reactions. It has a melting point around 115-117°C and a boiling point of about 320°C at 760 mmHg.

Ethyl 5-amino-1-benzofuran-2-carboxylate (CAS: 174775-48-5) can be synthesized via a multi-step process starting with ethyl benzoate and aniline. The key steps involve condensation followed by alkylation, then reduction, and finally the formation of the amino group. Commonly used catalysts include various Lewis acids and transition metal complexes. The overall yield is around 70-80%, and the method is selective and efficient.

Ethyl 5-amino-1-benzofuran-2-carboxylate (CAS: 174775-48-5) is primarily used in the pharmaceutical industry for the synthesis of drugs and intermediates. It is also utilized in the polymer industry for enhancing the properties of certain polymers. Additionally, it finds applications in the sensor technology and semiconductor industries for developing advanced materials with specific functional groups.

When handling Ethyl 5-amino-1-benzofuran-2-carboxylate (CAS: 174775-48-5), it is crucial to wear appropriate personal protective equipment (PPE), including gloves, goggles, and a lab coat. The compound should be stored in a cool, dry place away from direct sunlight and heat sources. In case of spills, ensure proper ventilation and use appropriate cleanup materials. Always consult the Safety Data Sheet (SDS) for detailed handling and disposal instructions.